Does Propranolol, a Beta Blocker, Attenuate Stress-Induced Drinking?

Status Recruiting

Clinical Trial Summary

For this protocol, the investigators plan to conduct a pilot study evaluating the effect of propranolol on alcohol consumption. Using a parallel design, the investigators plan to randomize 20 non-treatment seeking adults with alcohol use disorders (DSM-5) to propranolol extended release (160mg/day or placebo; n=10 per cell) to evaluate whether propranolol reduces alcohol self-administered in the laboratory. Importantly, the investigators will evaluate whether propranolol counteracts stress-induced effects on alcohol self-administration. Following titration to steady state medication levels over a 2-week period, each subject will complete two laboratory sessions consisting of a well validated method for inducing stress or neutral/relaxing state (order counterbalanced), followed by a 2-hour alcohol self-administration paradigm known to be sensitive to medication effects.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Alcohol Drinking

Clinical Trial Details

NCT number	NCT03588754
Study type	Interventional
Source	Yale University
Contact	Sabrina Coppola
Phone	203-737-2827
Email	sabrina.coppola@yale.edu
Status	Recruiting
Phase	Phase 2
Start date	September 15, 2018
Completion date	February 28, 2025

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT05414344` - A Brief Intervention for Alcohol Users With Interpersonal Trauma	N/A
Completed	`NCT05521906` - Evaluation of PRYSHM for LGBTQIA2S+ Youth	N/A
Not yet recruiting	`NCT04786587` - Alcohol Self-reporting During Pregnancy. AUTOQUEST Study.
Withdrawn	`NCT04659278` - Endourage Complete Spectrum Oral Mucosal Drops (OMD) in Adults Desiring a Reduction in Ethanol Use	N/A
Not yet recruiting	`NCT03632408` - Hangover and Residual Zopiclone Effect on Spatial Perception	Phase 1
Completed	`NCT02718508` - An e-Parenting Skills Intervention to Decrease Injured Adolescents' Alcohol Use	N/A
Active, not recruiting	`NCT02629679` - Sports, Education and Consumption of Substances in Adolescents	N/A
Completed	`NCT02945371` - Tailored Inhibitory Control Training to Reverse EA-linked Deficits in Mid-life	N/A
Completed	`NCT01553136` - Varenicline Treatment of Alcohol Dependence in Smokers	Phase 2
Completed	`NCT01442753` - Family-Skills Training to Prevent Tobacco and Other Substance Use in Latino Youth	N/A
Completed	`NCT01081119` - Brief Voluntary Alcohol and Drug Intervention for Middle School Youth	Phase 2
Completed	`NCT00289965` - Substance Use Risk Education (SURE) Project	Phase 2
Completed	`NCT04510116` - Adults In The Making Prevention Trial	N/A
Completed	`NCT00506753` - Motivation and Skills for Delta-9-tetrahydrocannabinol/Ethanol (THC/ETOH+) Teens in Jail	N/A
Recruiting	`NCT05288790` - Microbiome Metabolites and Alcohol in HIV to Reduce CVD RCT	Phase 2
Recruiting	`NCT05620849` - Young Adult Education on Alcohol & Health	N/A
Recruiting	`NCT04054466` - Nursing Counseling to the Change of Behavior of Alcohol Consumption in Patients in HAART	N/A
Recruiting	`NCT06074341` - TeleHealth Resources for IndiVidualizEd Goals (THRIVE) in Alcohol Recovery Study	N/A
Terminated	`NCT04596267` - Pitolisant Effects on Alcohol Self-Administration in Heavy Drinkers	Phase 1
Completed	`NCT03488927` - Development and Pilot Trial of an Intervention to Reduce Disclosure Recipients Negative Social Reactions and Victims Psychological Distress and Problem Drinking	N/A