Cocaine Addiction Clinical Trial
Official title:
The Effect of N-acetylcysteine (NAC) on Treatment of Alcohol and Cocaine Use Disorders: A Double-Blind Randomized Controlled Trial.
This study evaluates the use of N-acetylcysteine in the treatment of alcohol and cocaine use disorders. Alcohol users will be split in two groups, one will receive the active N-acetylcysteine and the other placebo. The same division will occur with cocaine users. The effects of N-acetylcysteine in adherence, abstinence, psychiatric symptoms and stress biomarkers will be evaluated.
N-acetylcysteine acts replenishing the human body glutathione storages. Glutathione is an
important antioxidant agent, and also modulates the N-methyl-D-aspartate (NMDA)
glutamatergic receptor. Glutamate has been associated with the neuroadaptation related to
substance use disorders, and thus it is considered a potential target for pharmacological
interventions regarding these disorders. N-acetylcysteine also interacts with the
cystine-glutamate antiporter on astrocytes hence increasing glutamate release into the
extracellular space.
N-acetylcysteine effects and its implications in the addiction disorders have been studied
initially with animal models. Glutamate levels normalization through N-acetylcysteine
reduced compulsive drug self-administration and drug-seeking behavior in mice. In addition,
there are promising results also with human subjects, showing benefits for cocaine, alcohol
and cannabis use disorders.
This study consists of a randomized, double-blind, placebo controlled trial with four arms:
alcohol users divided into NAC vs Placebo and cocaine users divided into NAC vs Placebo.
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