Nausea Clinical Trial
Study Objective:
The purpose of this study is to compare the effects of metoclopramide administration in
bolus versus slow infusion medications in ED patients complaining of nausea for the
determination of the therapeutic effect and prevention of akathisia.
Methods:
This was a prospective, randomized, double-blind trial. The investigation was held between
01 March 2007 and 01 May 2008, in the Emergency Department of Pamukkale University Faculty
of Medicine. The patients with moderate to severe nausea randomized and divided into two
groups as for the previously planned administration type of drug. Ten mg metoclopramide was
administered in one group with slow infusion (SIG) in 15 minutes, via 2 minutes bolus
infusion (BIG) into the other group. Whole procedure was observed, akathisia and nausea
scores and vital changes were recorded.
n/a
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Prevention
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