The Effect of Esomeprazole and Fundoplication on Airways

Airway Responsiveness Clinical Trial

Official title: The Effect of Esomeprazole and Nissen Fundoplication on Bronchial Responsiveness, Quality of Life, Exhaled Nitric Oxide and Pulmonary Function in Patients With Gastroesophageal Reflux Disease

Status Completed

Clinical Trial Summary

Evaluate the prevalence of bronchial responsiveness (BHR) among patients with gastroesophageal reflux disease (GERD).

Investigate correlation between bronchial reactivity and the severity of GERD, and similarly investigate the correlation between exhaled nitric oxide (NO) and the severity of GERD.

Compare the effects of esomeprazole 40 mg twice daily and Nissen fundoplication on bronchial reactivity, exhaled NO, pulmonary function and quality of life.

Clinical Trial Description

n/a

Study Design

N/A

Related Conditions & MeSH terms

• Airway Responsiveness
• Gastroesophageal Reflux

• NCT number: NCT00994708
• Study type: Interventional
• Source: Tampere University Hospital
• Status: Completed
• Phase: Phase 3
• Start date: December 2004