Airway Obstruction Clinical Trial
Official title:
The Effect of Heliox on the Work of Breathing in Adult Patients With Lower Airway Stenosis
Heliox (a mixture of Helium and Oxygen) can reduce the work of breathing in patients with airway stenosis by modifying turbulent flow into laminar flow. The aim of this study was to analyze the effect of Heliox versus conventional oxygen therapy in patients with lower airway stenosis on muscular effort measured by electromyography and diaphragmatic ultrasound, thoracoabdominal synchrony assessed with plethysmographic bands, dyspnea, stridor, oxygen saturation, transcutaneous carbon dioxide value, blood pressure, heart rate and respiratory rate.
Lower airway stenosis results in increased work of breathing with stridor and dyspnea, as a consequence of the increased resistances caused by the reduction in airway diameter. Airway resistance also depends on the length of the airway and the type of gas flow. Heliox (a mixture of Helium and Oxygen) is a gas less dense than air, which can change the flow from turbulent to laminar, reducing airway resistance by 20 to 40%, and therefore decreasing the work of breathing. Heliox is an inert gas that does not react with biological membranes, so there are few complications associated with its use, the most relevant being hypoxemia when fixed mixtures are not used and the the fraction of inspired oxygen (FiO2) supplied is less than 21%. The aim of the study was to evaluate if during the perioperative period of lower airway stenosis the administration of Heliox compared to oxygen could reduce the work of breathing and improve dyspnea. For this purpose, patients were treated for 30 minutes with Heliox (fixed mixture of 70% helium and 30% oxygen) using a non rebreather mask or reservoir bag versus 30 minutes with oxygen 31% using a Venturi mask. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Enrolling by invitation |
NCT04506346 -
Risk Prediction of Difficult Tracheal Intubation in OSAHS Patient
|
||
| Completed |
NCT02106143 -
RejuvenAir™ System Lobectomy Safety and Histology Study
|
N/A | |
| Completed |
NCT03274791 -
Clinical Features and Airways Inflammation in Never Smokers and Smokers With COPD
|
N/A | |
| Completed |
NCT01765530 -
Efficacy Study of a Novel Device to Clean the Endotracheal Tube
|
N/A | |
| Completed |
NCT01721486 -
Acetaminophen's Efficacy For Post-operative Pain
|
Phase 4 | |
| Completed |
NCT03656315 -
Scoring System to Predict Depth of Cricothyroid Membrane
|
N/A | |
| Recruiting |
NCT05880836 -
In Line Aerosol Nebulization With High Flow
|
N/A | |
| Recruiting |
NCT05573919 -
VivAer: A Correlation Between Symptom Scores and Objective Findings
|
N/A | |
| Completed |
NCT02403934 -
Jaw Elevation Device in Deep Sedation Study
|
N/A | |
| Recruiting |
NCT00452062 -
Dexamethasone and the Prevention of Post-Extubation Airway Obstruction in Adults
|
Phase 2 | |
| Completed |
NCT02563210 -
Airway Resistance Measurement in Children 3 to 6 Years of Age
|
N/A | |
| Completed |
NCT03488849 -
SureCRIC Standardized Patient Study
|
||
| Completed |
NCT03752593 -
The Incidence of Difficult Intubation in Obese Versus Non-obese Patients
|
||
| Recruiting |
NCT05974488 -
The Efficacy of Distal Pharyngeal Airway for Oxygenation During TEE
|
N/A | |
| Not yet recruiting |
NCT02975791 -
Ultrasonography Versus Palpation for Identification of the Cricothyroid Membrane
|
N/A | |
| Completed |
NCT00788788 -
Heliox in Experimental Upper Airway Obstruction
|
Phase 1/Phase 2 | |
| Not yet recruiting |
NCT06128811 -
Dental Isolation Systems Among Pediatric Patients With Different Airway Patency
|
N/A | |
| Completed |
NCT05550220 -
A Modified Cuff Leak Test and Reintubation in Mechanically Ventilated Patients
|
N/A | |
| Completed |
NCT03165461 -
Evaluation of the Use of Tracheal Intubation Through a Laryngeal Tube to Intubate Anesthetized Patients
|
||
| Recruiting |
NCT03969147 -
Investigation of a Novel Oropharyngeal Airway: The ManMaxAirway
|
N/A |