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Agranulocytosis clinical trials

View clinical trials related to Agranulocytosis.

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NCT ID: NCT05349383 Completed - Clinical trials for Opportunistic Infections

Evaluation of Reporting of Antibody-Drug Conjugate Associated Sepsis-related Toxicities

Start date: April 22, 2022
Phase:
Study type: Observational

Although antibody-drug conjugate(ADC) has proved effective in treating many cancers, few patients receiving ADC may experience rare but life-threatening sepsis-related toxicities such as sepsis and septic shock. Today, data about sepsis/septic shock are scarce. The objective was to investigate reports of sepsis/septic shock adverse events related to ADC, including Gemtuzumab Ozogamicin, Trastuzumab Emtansine, Inotuzumab Ozogamicin, Enfortumab vedotin, Trastuzumab deruxtecan, Sacituzumab govitecan, Brentuximab Vedotin, Moxetumomab pasudotox, Polatuzumab Vedotin, Belantamab Mafodotin, loncastuximab tesirine and Tisotumab vedotin using international pharmacovigilance databases such as the FDA Adverse Event Reporting System (FAERS).

NCT ID: NCT03857399 Completed - Fungal Infection Clinical Trials

Empiric Therapy of Patients With Persistent Fever and Agranulocytosis Using Caspofungin

Start date: September 17, 2018
Phase: Phase 2
Study type: Interventional

The purpose of this study is evaluating the efficacy and safety of generics caspofungin in the treatment of the patients with neutropenic and fever.Another purpose of this study is comparing the pharmacokinetic characteristics of generics caspofungin and original medicine(Cancidas®) for providing a basis for clinical rational administration.

NCT ID: NCT00059423 Completed - Neutropenia Clinical Trials

Natural History Study for BEN

Start date: June 3, 2003
Phase:
Study type: Observational

In recent decades, hematologists have noticed that persons of African descent sometimes have lower white blood cell counts of a certain type, called granulocytes. These cells help to fight infections. The lower number of granulocytes in this situation does not appear to lead to more infections, and these individuals do not have any symptoms. This condition is called benign ethnic neutropenia (BEN), and is observed in a small percentage of individuals of African descent. This study will investigate the condition by studying people with and without BEN. The goals of this study are to: 1. identify individuals of African descent with BEN. 2. determine the effects of two drugs, G-CSF and dexamethasone, on granulocyte production and movement. 3. determine whether there are differences in those with and without BEN in the way genes are stimulated after the administration of G-CSF and dexamethasone. Study participants will be asked to interview with the research team, undergo physical exams, donate a blood sample, and receive G-CSF by injection, followed by dexamethasone (orally) about three weeks later. They also will be required to undergo apheresis three times, a procedure in which blood is drawn from a donor and separated into its components. Some components are retained for research analyses, such as granulocytes, and small amount of blood; the remainder is returned by transfusion to the donor. This procedure will be required of participants before they receive G-CSF, the day after they receive G-CSF, and the day after they receive dexamethasone. Gene messages (mRNA will be isolated from granulocytes, and analyzed to better understand granulocyte growth and movement.

NCT ID: NCT00005307 Completed - Blood Disease Clinical Trials

Etiology of Blood Dyscrasias: Analysis of the International Agranulocytosis and Aplastic Anemia Study Data

Start date: April 1989
Phase: N/A
Study type: Observational

To quantify the role of drugs and other factors in the etiology of agranulocytosis and aplastic anemia.

NCT ID: NCT00005302 Completed - Blood Disease Clinical Trials

Drug Etiology of Aplastic Anemia and Related Dyscrasias

Start date: April 1985
Phase: N/A
Study type: Observational

To determine the role of drugs in the etiology of aplastic anemia, agranulocytosis, and thrombocytopenic purpura. Drugs used in chemotherapy and immunotherapy were excluded.