Mechanisms of Panic Disorders Treatment

Status Recruiting

Clinical Trial Summary

Investigation of mechanisms of exposure based learning by

1. Investigating the effects of fear augmentation by interoceptive exposure during in vivo exposure

2. Disentangling the effects of interoceptive exposure exercises in panic disorder

Clinical Trial Description

The study aims on investigating the effect of fear augmentation during in-vivo exposure by adding interoceptive exposure (e.g., hyperventilation) in PD/AG patients. By comparing the fear augmentation group with the therapist-guided CBT exposure, and by measuring autonomic arousal during and between exposure sessions, it will be possible to study the mechanisms of exposure based learning. A second aim is to disentangle effects of specific interoceptive exposure exercises (e.g., respiratory vs. vestibular stimulation). Finally, by including patients without agoraphobic avoidance it will be possible to investigate whether interoceptive exposure alone will have any effect. This might open the door for early interventions for individuals after experiencing an initial panic attack to prevent the development of a severe panic disorder with agoraphobic avoidance. ;

Study Design

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT01323556
Study type	Interventional
Source	University Medicine Greifswald
Contact	Alfons O Hamm, PhD
Phone	+49 (0)3834-863716
Email	hamm@uni-greifswald.de
Status	Recruiting
Phase	Phase 2/Phase 3
Start date	March 2010
Completion date	May 2012

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