Agitation Clinical Trial
Official title:
A Comparison Study of the Efficacy of a Rapid Titration of Quetiapine and Haloperidol in Agitated Adults in an Emergency Setting.
In the Psychiatric Emergency Room, agitated patients are treated routinely with an I.M. Haloperidol "cocktail" (Haloperidol 5 mg, Lorazepam 2 mg, Cogentin 2 mg), which has proved to be an effective treatment. However, since it is an intramuscular injection, it is more complicated and perhaps less acceptable to patients as well as more likely to cause EPS (extrapyramidal symptoms). Of late in our emergency room, we started using high dose Quetiapine 300 mg PO to replace the "cocktail" for treating agitation. It has shown promising results.
In the Psychiatric Emergency Room, agitated patients are treated routinely with an I.M.
Haloperidol "cocktail" (Haloperidol 5 mg, Lorazepam 2 mg, Cogentin 2 mg), which has proved to
be an effective treatment. However, since it is an intramuscular injection, it is more
complicated and perhaps less acceptable to patients as well as more likely to cause EPS
(extrapyramidal symptoms). Of late in our emergency room, we started using high dose
Quetiapine 300 mg PO to replace the "cocktail" for treating agitation. It has shown promising
results.
This study is designed to compare the efficacy and safety of Quetiapine with the routine
"cocktail for treatment of agitation.
The primary purpose of this study is to determine the efficacy and safety of Quetiapine by
using high dose Quetiapine (300 mg) PO to treat agitated patients in the psychiatric
emergency room.
The secondary purpose is to test the immediate effect on agitation caused by illicit drug
abuse or the alcohol abuse.
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