Aging Well Clinical Trial
Official title:
Assessing Causality of the Association Between Exercise and Neurocognitive Gains
Brief Summary: The aim of this project is to examine: 1. The effects of a community based square stepping exercise programme on cognitive and physical functions in older adults. 2. The effects of a community based square stepping exercise programme on neuroplasticity in older adults. 3. The effects of a community based square stepping exercise programme on structural and functional brain changes in older adults. 4. The relationship between exercise-induced changes in neuroplasticity, structural and functional brain activations, and cognitive and physical gains in older adults.
It is well known regular exercise produces both physical and cognitive benefits. Emerging evidence suggests that physical movements or exercise that have concurrent cognitive demands may have more profound effects on cognitive and brain health outcomes. One training program that incorporates these components is the square stepping exercise (SSE). First demonstrated in Japan, this community-based paradigm has already shown to reduce falls risk and presents as a convenient exercise modality for older adults, that can be conducted in a group setting or even the home. The current project aims to examine the efficacy of this SSE community programme in a Singapore context on cognitive and physical health in older adults. This study also aims to quantify the neural correlates underpinning any observed improvements in cognitive and physical function. Specifically, this project will measure indices of neuroplasticity via structural and functional magnetic resonance imaging, transcranial magnetic stimulation, and electroencephalography. Sample size estimation: n=80 for behavioural primary outcome measures and n=40 subset of larger sample for neuroimaging and neuroplasticity secondary outcome measures [anticipated]. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Not yet recruiting |
NCT06040554 -
The Effect Of A Resistance Exercise Program On Balance Of Elderly People
|
N/A | |
| Recruiting |
NCT04518423 -
Prevalence, Determinants and Natural History of Frailty and Pre-frailty in Elderly People
|
||
| Recruiting |
NCT05071326 -
Healthy Lifetime - Sustainability and Quality Study
|
N/A | |
| Completed |
NCT05135819 -
Cyber School for Grandparents: an Intergenerational Educational Program
|
N/A | |
| Recruiting |
NCT05573646 -
Online Group-based Dual-task Training to Improve Cognitive Function of Community-dwelling Older Adults
|
N/A | |
| Terminated |
NCT05024903 -
A Novel E-health Platform
|
Phase 2/Phase 3 | |
| Completed |
NCT04156074 -
Innovative Food Structures to Enhance Nutrient Bioavailability
|
N/A | |
| Recruiting |
NCT05706181 -
Heat Therapy, Functional Capacity, and Vascular Health in Older Adults
|
Phase 1/Phase 2 | |
| Withdrawn |
NCT04842864 -
Time Course for Fasting-induced Autophagy in Humans
|
N/A | |
| Terminated |
NCT04889131 -
Yoga for Seniors
|
N/A | |
| Recruiting |
NCT06085196 -
Mindful Walking Program for Older African Americans
|
N/A | |
| Completed |
NCT04828018 -
Care of the Ageing Veteran Population: Developing an Evidence Base for the Royal Hospital Chelsea Model of Care
|
||
| Completed |
NCT06308458 -
Breather Exerciser Trainer on Diaphragmatic Mobility And Thickness
|
N/A | |
| Not yet recruiting |
NCT05001646 -
Electromagnetic Field Protection Device Use Impact in Healthy Volunteers
|
Phase 2 | |
| Recruiting |
NCT06219148 -
Music Therapy and Social Work Telehealth for Older Adult Well-Being
|
N/A | |
| Not yet recruiting |
NCT06295354 -
Early Variations in Immune Aging
|
||
| Not yet recruiting |
NCT04734951 -
Muscle Quality Index Improvement by Exercise and HMB Oral Supplementation in Older Adults
|
N/A | |
| Completed |
NCT05456594 -
Comparing Sports Bra Design in Full Busted Women
|
N/A | |
| Recruiting |
NCT06217601 -
Impact Evaluation of the Digital Connect Project for Homebound Older Adults
|
N/A | |
| Recruiting |
NCT05920733 -
Healthy Lifetime - Phase 2
|
N/A |