Clinical Trials Logo
  1. Home
  2. Aggressive Periodontitis
  3. NCT05975892

Transplantation of Bone Marrow Mesenchymal Stromal Cells for Periodontal Regeneration — BMMSC  

Aggressive Periodontitis Clinical Trial

Official title:
Transplantation of Bone Marrow Mesenchymal Stromal Cells for Bone Regeneration in Periodontal Disease

Clinical Trial Summary

The goal of this study is to evaluate the capacity of allogeneic bone marrow mesenchymal stromal cells (MSC) to induce bone regeneration in patients with periodontal disease. MSC cultured are loaded on a collagen scaffold, included into autologous platelet rich plasma clot and implanted in the bone defect.

Clinical Trial Description

The clinical protocol is designed to evaluate the bone regeneration capacity of allogeneic MSCs for the treatment of patients with chronic or aggressive periodontal disease. Patients with either a 2- or 3-wall intrabony defects are included in this study. A bioengineering construct, constituted by allogeneic MSCs and a collagen scaffold, is incorporated into platelet rich plasma (PRP) clot, which is implanted at the bone defect site. Follow up of treated tooth are assessed by clinical evaluation, intraoral radiography and cone-beam CT. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05975892
Study type Interventional
Source Instituto Venezolano de Investigaciones Cientificas
Contact
Status Enrolling by invitation
Phase Phase 1/Phase 2
Start date August 30, 2018
Completion date August 30, 2024
View Details
See also
  Status Clinical Trial Phase
Recruiting NCT05043935 - The Effect of Leukocyte and Platelet-rich Fibrin With Antimicrobial Photodynamic Therapy in Aggressive Periodontitis N/A
Terminated NCT01993368 - Analysis of Osteoimmune Interactions Linking Inflammation and Bone Destruction in Aggressive Periodontitis N/A
Completed NCT02282800 - Immunolocalization of 1,25,Dihydroxyvitamin D3 in Aggressive Periodontitis Patients N/A
Recruiting NCT02833285 - B Cell Functions in Periodontitis
Completed NCT02127203 - Nitro-oxidative Stress in Periodontitis N/A
Completed NCT02223702 - Alternative Antibiotic Regime in the Treatment of GAgP Phase 4
Completed NCT03093207 - Omega-3 Fatty Acids Plus Low-dose Aspirin Daily Supplementation in Surgical Therapy to Treat Aggressive Periodontitis Phase 2/Phase 3
Completed NCT03093246 - Omega-3 Plus Low-dose Aspirin Daily Supplementation in Non-surgical Therapy to Treat Aggressive Periodontitis Phase 2/Phase 3
Completed NCT05297084 - Non Surgical Periodontal Treatment Effect on Il-17 and Il-18 in Aggressive Periodontitis
Completed NCT05295576 - Effect of Non Surgical Periodontal Therapy on Inflammatory Markers in Chronic Periodontitis Patients
Completed NCT02969928 - Two Different Antibiotic Agents to Treat Generalized Aggressive Periodontitis Phase 2/Phase 3
Completed NCT02829983 - Clarithromycin as Adjuvant to Periodontal Debridement N/A
Completed NCT02927704 - Gingival Crevicular Fluid Levels Of Monocyte Chemoattractant Protein-1 N/A
Completed NCT02817568 - Frequency Of MCP-1 And CCR2 Gene Polymorphisms And Its Effect On Gene Expression In Patients With AgP N/A
Active, not recruiting NCT04051255 - Influence of Smoking on Clinical, Microbiological and Immunologic Parameters in Patients With Aggressive Periodontitis. N/A
Completed NCT05001919 - Concentrated Growth Factors in Treatment of Intrabony Defects in Localized Aggressive Periodontitis Phase 1/Phase 2
Completed NCT03727620 - Doxycycline in the Treatment of Aggressive Periodontitis Phase 1/Phase 2
Completed NCT04223869 - IL-34 Levels in Various Types of Periodontitis N/A
Completed NCT03034824 - Effects of Er,Cr:YSGG, Diode Lasers on GCF Cytokines Levels N/A
Completed NCT02049008 - Treatment of Aggressive Periodontitis With Repeated Adjunctive Antimicrobial Photodynamic Therapy Phase 4