Periodontal Diseases Clinical Trial
Official title:
Influence of Smoking on Clinical, Microbiological and Immunologic Parameters in Patients With Aggressive Periodontitis Treated With Non-surgical Mechanical Therapy Associated With Systemic Antibiotic Therapy.
Treatment of smoker patients with AgP is considered a challenge to periodontists. To date,
only one controlled clinical study (De Genaro Modanese et al., 2016) evaluated the effect of
full mouth ultrasonic debridment (FMUD) on smokers with aggressive periodontitis. Its results
showed significant improvements in clinical parameters (plaque index PI, bleeding on probing-
BoP and probing depth-PD), and immunologic (reductions in interleukin 6- IL-6, tumor necrosis
factor- α TNF-α levels), although the results were more favorable for non-smoking patients.
Antimicrobials associated to mechanical therapy has been extensively studied (Hafajee et al.,
2003, Heitz-Mayfield, 2006). The association of Amoxicillin and Metronidazole have had good
clinical and microbiological results in randomized clinical trials in the treatment of AgP
(Casarin et al., 2012, Sgolastra et al., 2012, Keestra et al., 2015).
Thus, this study investigates clinical, microbiological and immunological influence of
smoking in the periodontal debridement associated to Amoxiciclin and Metronidazole of young
individuals with pronounced periodontal destruction, compared with non-smokers individuals.
n/a
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