Aggressive Periodontitis Clinical Trial
Official title:
Gingival Crevicular Fluid Levels Of Monocyte Chemoattractant Protein-1 in Patients With Aggressive Periodontitis
The aim of this study is to estimate GCF MCP-1 levels of healthy and Aggressive periodontitis (AgP) subjects and to compare MCP-1 levels between Localized AgP (LAgP) and Generalized AgP (GAgP) to establish its predictive value/role for distinguishing LAgP and GAgP development.
Patients with aggressive periodontitis (AgP) are diagnosed as rapid and severe periodontal
destruction commonly in younger systemically healthy individuals (Armitage, 1999). Although
periopathogenic bacteria are essential for initiation, this alone does not be responsible
for the manifestation and severity of the clinical status/phenotype (Offenbacher et al.,
2008), suggesting an imbalance between host and bacterial load (Kinane et al., 2007).
Response to bacterial biofilm is determined by the host immune system (Mahanonda and
Pichyangkul, 2007, Amano, 2010) in which genetic and enviromental factors modify and may get
individuals more susceptible or resistant to the periodontal diseases (Kulkarni and Kinane,
2014).
The role of whether an impaired or a hyperinflammatory host response is responsible for the
progression of aggressive periodontitis has been a topic of discussion. Regarding to this
topic Shaddox et al. (2016) studied the whole blood specimens collected from LAgP subjects
and stimulated with plaque sample generated from healthy or diseased sites. And as a result,
LAgP subjects displayed hyperinflammatory response regardless of contents of bacterial
stimulus. In an another research hyperinflammatory responders LAgP subjects presented the
lowest reductions in clinical parameters, on the contrary low responders showed the highest
reductions after treatment (Allin et al., 2016). Similarly Garrison and Nichols (1989)
reported that hyper-inflammatory monocyte phenotype can be deterministic in periodontal
destruction. In the view of the aforementioned findings, the aim of this study is to
estimate GCF MCP-1 levels of healthy and AgP subjects and to compare MCP-1 levels between
LAgP and GAgP to establish its predictive value/role for distinguishing LAgP and GAgP
development.
A total of 160 subjects including, 80 AgP and 80 age and gender matched periodontally
healthy (H) controls were recruited in this cross-sectional study. Clinical periodontal
measurements including plaque index (PI), gingival index (GI), proping depth (PD) and
clinical attachment loss (CAL) were performed. GCF samples were collected from 160 patients
including 50 LAgP, 30 GAgP and 80 H. Volume of GCF samples were measured by an electronic
device (Periotron 8000, OroFlow Inc.) and GCF MCP-1 was measured by an enzyme-linked
immunosorbent assay "ELISA".
;
Observational Model: Case Control, Time Perspective: Cross-Sectional
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT05043935 -
The Effect of Leukocyte and Platelet-rich Fibrin With Antimicrobial Photodynamic Therapy in Aggressive Periodontitis
|
N/A | |
Terminated |
NCT01993368 -
Analysis of Osteoimmune Interactions Linking Inflammation and Bone Destruction in Aggressive Periodontitis
|
N/A | |
Completed |
NCT02282800 -
Immunolocalization of 1,25,Dihydroxyvitamin D3 in Aggressive Periodontitis Patients
|
N/A | |
Recruiting |
NCT02833285 -
B Cell Functions in Periodontitis
|
||
Completed |
NCT02127203 -
Nitro-oxidative Stress in Periodontitis
|
N/A | |
Completed |
NCT02223702 -
Alternative Antibiotic Regime in the Treatment of GAgP
|
Phase 4 | |
Completed |
NCT03093207 -
Omega-3 Fatty Acids Plus Low-dose Aspirin Daily Supplementation in Surgical Therapy to Treat Aggressive Periodontitis
|
Phase 2/Phase 3 | |
Completed |
NCT03093246 -
Omega-3 Plus Low-dose Aspirin Daily Supplementation in Non-surgical Therapy to Treat Aggressive Periodontitis
|
Phase 2/Phase 3 | |
Completed |
NCT05295576 -
Effect of Non Surgical Periodontal Therapy on Inflammatory Markers in Chronic Periodontitis Patients
|
||
Completed |
NCT05297084 -
Non Surgical Periodontal Treatment Effect on Il-17 and Il-18 in Aggressive Periodontitis
|
||
Completed |
NCT02969928 -
Two Different Antibiotic Agents to Treat Generalized Aggressive Periodontitis
|
Phase 2/Phase 3 | |
Completed |
NCT02829983 -
Clarithromycin as Adjuvant to Periodontal Debridement
|
N/A | |
Completed |
NCT02817568 -
Frequency Of MCP-1 And CCR2 Gene Polymorphisms And Its Effect On Gene Expression In Patients With AgP
|
N/A | |
Active, not recruiting |
NCT04051255 -
Influence of Smoking on Clinical, Microbiological and Immunologic Parameters in Patients With Aggressive Periodontitis.
|
N/A | |
Completed |
NCT05001919 -
Concentrated Growth Factors in Treatment of Intrabony Defects in Localized Aggressive Periodontitis
|
Phase 1/Phase 2 | |
Completed |
NCT03727620 -
Doxycycline in the Treatment of Aggressive Periodontitis
|
Phase 1/Phase 2 | |
Completed |
NCT04223869 -
IL-34 Levels in Various Types of Periodontitis
|
N/A | |
Completed |
NCT03034824 -
Effects of Er,Cr:YSGG, Diode Lasers on GCF Cytokines Levels
|
N/A | |
Completed |
NCT02049008 -
Treatment of Aggressive Periodontitis With Repeated Adjunctive Antimicrobial Photodynamic Therapy
|
Phase 4 | |
Recruiting |
NCT01510808 -
The Affect of Orthodontic Treatment on the Periodontal Status of Patients With Aggressive Periodontitis
|
N/A |