Chronic Periodontitis Clinical Trial
Official title:
Periodontitis and Inflammation : Biological and Clinical Approach of B Cell Role.
The inflammatory response involves many players from the immune response, including B
lymphocytes. These cells are responsible for the synthesis of immunoglobulins in response to
the presence of an antigen. They are characteristic of chronic inflammation. There are
several subsets of B cells characterized by specific membrane markers. Once activated, these
cells express many factors contributing to tissue destruction seen in periodontitis and
particularly in osteoclastogenesis (receptor activator of nuclear factor kappa-B ligand,
tumor necrosis factor, interleukin-6, macrophage inflammatory protein-1α and Monocyte
Chemoattractant Protein-3).
During the establishment of a periodontal disease, an important inflammatory infiltrate is
observed in the gum. This infiltrate is characterized by the presence of many B lymphocytes.
B cell subsets in the blood and the gum of patients with periodontitis have been little
studied. However, the number of autoreactive B cells (cluster of differentiation (CD)19+,
CD5+) has been reported to be higher in the blood of patients with periodontal disease. In
the gum, the rate of B and T cells increases with the level of inflammation and is correlated
with the severity of the inflammatory process. Activation of B cells is a prerequisite for
the progression of gingivitis to periodontitis. B cell distribution could then be an
indicator of disease progression, but also allow to study the response to treatment.
The aim of this pilot study is to characterize B cell subsets in the blood and the gum of
patients with periodontitis, according to disease activity. Analysis of B cells in the blood
could highlight the association of a particular subpopulation with aggressive periodontal
disease and evidence a particular biological profile of the host response. The investigators
also wish to observe the evolution of this phenotype following an unconventional surgical
therapy.
This study would better understand the pathogenesis of periodontal disease and refine the
diagnosis, prognosis and treatment of periodontitis, and thus participate in the development
of personalized medicine. Biological monitoring of therapeutic effects may be initiated and
allow more effectively prevent recurrence.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Not yet recruiting |
NCT06400069 -
Role of NLRP6 in Chronic Periodontitis
|
||
| Completed |
NCT05231096 -
Comparison of the Effect of Gingival Massage of Aloe-vera Gel and Sidr Honey on Chronic Periodontitis
|
N/A | |
| Completed |
NCT03203746 -
Gingival Crevicular Fluid Levels of Protein Carbonyl Following the Use of Lycopene in Chronic Periodontitis
|
Phase 1/Phase 2 | |
| Active, not recruiting |
NCT03354338 -
Amoxicillin to Prevent Bacteria and Inflammatory Biomarkers After Intensive Periodontal Therapy
|
Phase 2 | |
| Completed |
NCT02516111 -
Comparison of Autologous PRF, 1% Alendronate and 1.2% Atorvastatin Gel in Chronic Periodontitis Treatment
|
Phase 2/Phase 3 | |
| Completed |
NCT02174146 -
Leptin and Visfatin in Diabetic Patients With Periodontitis Before and After Periodontal Therapy
|
N/A | |
| Terminated |
NCT02568163 -
Influence of Stress on Non Surgical Periodontal Treatment
|
N/A | |
| Completed |
NCT02430519 -
Benefits of Platelet Rich Fibrin In Mandibular Molar Furcation Defects
|
N/A | |
| Completed |
NCT01438333 -
Efficacy of INERSAN in Patients With Chronic Periodontitis as Adjunctive to Full Mouth Disinfection
|
N/A | |
| Completed |
NCT01233765 -
Analysis of Neutrophil Response in Chronic Periodontitis
|
N/A | |
| Completed |
NCT02218515 -
Treatment of Intrabony Periodontal Defects With Enamel Matrix Derivatives and Autogenous Bone Graft
|
Phase 4 | |
| Completed |
NCT02197260 -
Antimicrobial Therapy as Adjunct to Periodontal Treatment: Effect of Timing
|
Phase 4 | |
| Not yet recruiting |
NCT03270280 -
Comparison of Salivary Interleukin-1β and Matrix Metalloproteinase-8 Levels in Individuals With Chronic Periodontitis
|
Phase 2 | |
| Not yet recruiting |
NCT04026828 -
Evaluation of Possible Genes in Periodontal Diseases by Genetic Methods
|
||
| Completed |
NCT04697199 -
The Adjunctive Effect of Probiotics to Non Surgical Treatment of Chronic Periodontitis
|
Phase 1 | |
| Completed |
NCT04643288 -
Nanocrystalline Hydroxyapatite Bone Substitute for Treating Periodontal Intrabony Defects
|
N/A | |
| Completed |
NCT03039244 -
Evaluation of Antimicrobial Photodynamic Therapy as an Adjunct to Periodontal Treatment in Smokers
|
N/A | |
| Completed |
NCT02851823 -
Combined Use of Er:YAG and Nd:YAG Laser
|
N/A | |
| Completed |
NCT02518152 -
Platelet Rich Fibrin+1% Alendronate in Treatment of Chronic Periodontitis
|
Phase 2/Phase 3 | |
| Completed |
NCT02898675 -
Advantages of Autologous Platelet-Rich Fibrin Membrane on Growth Factor Levels and Periodontal Healing
|
N/A |