Aggressive Periodontitis Clinical Trial
Official title:
The Evaluation of MCP-1 and CCR-2 Gene Polymorphisms Frequency and The Effects of This Polymorphism on Gene Expression in Patients With Aggressive Periodontitis
Verified date | June 2016 |
Source | Abant Izzet Baysal University |
Contact | n/a |
Is FDA regulated | No |
Health authority | Turkey: Ethics Committee |
Study type | Observational |
The aim of this study is to estimate genetic impact of MCP-1 -2518 and its receptor CCR2 -190 polymorphisms on AgP patients among Turkish individuals and whether MCP-1 genotype effects mRNA levels of Peripheral Blood Mononuclear Cell Leukocyte (PBML)
Status | Completed |
Enrollment | 215 |
Est. completion date | August 2014 |
Est. primary completion date | August 2012 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 16 Years and older |
Eligibility |
Inclusion Criteria: - Periodontally H control group had < 3mm PD, < 2 GI and no signs of interproximal attachment loss and a history of periodontal disease. - The AgP group included individuals diagnosed with localized AgP (LAgP) or generalized AgP (GAgP) who were otherwise healthy. Periodontal attachment loss =4 mm not involving more than two permanent teeth, other than the first molars and incisors were diagnosed with LAgP (n: 43); patients with involvement of at least three teeth, other than the first molars and incisors with an attachment loss =4 mm were diagnosed with GAgP Exclusion Criteria: - Patients who have any systemic diseases or conditions that could effect the periodontium - hepatitis and/or immunodeficiency virus infection - a history of periodontal treatment and antibiotic therapy within the 6 months - < 16 teeth in their mouth - Subjects who had smoked and were ongoing orthodontic treatment were excluded. |
Observational Model: Case Control, Time Perspective: Cross-Sectional
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
Abant Izzet Baysal University | Selcuk University |
Armitage GC. Periodontal diagnoses and classification of periodontal diseases. Periodontol 2000. 2004;34:9-21. Review. — View Citation
Emingil G, Atilla G, Hüseyinov A. Gingival crevicular fluid monocyte chemoattractant protein-1 and RANTES levels in patients with generalized aggressive periodontitis. J Clin Periodontol. 2004 Oct;31(10):829-34. — View Citation
Kurtis B, Tüter G, Serdar M, Akdemir P, Uygur C, Firatli E, Bal B. Gingival crevicular fluid levels of monocyte chemoattractant protein-1 and tumor necrosis factor-alpha in patients with chronic and aggressive periodontitis. J Periodontol. 2005 Nov;76(11) — View Citation
Pradeep AR, Daisy H, Hadge P. Gingival crevicular fluid levels of monocyte chemoattractant protein-1 in periodontal health and disease. Arch Oral Biol. 2009 May;54(5):503-9. doi: 10.1016/j.archoralbio.2009.02.007. Epub 2009 Mar 16. — View Citation
Yu X, Graves DT. Fibroblasts, mononuclear phagocytes, and endothelial cells express monocyte chemoattractant protein-1 (MCP-1) in inflamed human gingiva. J Periodontol. 1995 Jan;66(1):80-8. — View Citation
Zhu XL, Meng HX, Zhang L, Xu L, Chen ZB, Shi D, Feng XH, Zhang X. Association analysis between the -2518MCP-1(A/G) polymorphism and generalized aggressive periodontitis in a Chinese population. J Periodontal Res. 2012 Jun;47(3):286-92. doi: 10.1111/j.1600 — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Frequency of MCP-1 -2518 A/G and CCR2 -190 G/A gene polymorphisms in Aggressive Periodontitis | one year | No | |
Secondary | MCP-1 gene expression in AgP patients | six months | No |
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT05043935 -
The Effect of Leukocyte and Platelet-rich Fibrin With Antimicrobial Photodynamic Therapy in Aggressive Periodontitis
|
N/A | |
Terminated |
NCT01993368 -
Analysis of Osteoimmune Interactions Linking Inflammation and Bone Destruction in Aggressive Periodontitis
|
N/A | |
Completed |
NCT02282800 -
Immunolocalization of 1,25,Dihydroxyvitamin D3 in Aggressive Periodontitis Patients
|
N/A | |
Recruiting |
NCT02833285 -
B Cell Functions in Periodontitis
|
||
Completed |
NCT02127203 -
Nitro-oxidative Stress in Periodontitis
|
N/A | |
Completed |
NCT02223702 -
Alternative Antibiotic Regime in the Treatment of GAgP
|
Phase 4 | |
Completed |
NCT03093246 -
Omega-3 Plus Low-dose Aspirin Daily Supplementation in Non-surgical Therapy to Treat Aggressive Periodontitis
|
Phase 2/Phase 3 | |
Completed |
NCT03093207 -
Omega-3 Fatty Acids Plus Low-dose Aspirin Daily Supplementation in Surgical Therapy to Treat Aggressive Periodontitis
|
Phase 2/Phase 3 | |
Completed |
NCT05295576 -
Effect of Non Surgical Periodontal Therapy on Inflammatory Markers in Chronic Periodontitis Patients
|
||
Completed |
NCT05297084 -
Non Surgical Periodontal Treatment Effect on Il-17 and Il-18 in Aggressive Periodontitis
|
||
Completed |
NCT02969928 -
Two Different Antibiotic Agents to Treat Generalized Aggressive Periodontitis
|
Phase 2/Phase 3 | |
Completed |
NCT02829983 -
Clarithromycin as Adjuvant to Periodontal Debridement
|
N/A | |
Completed |
NCT02927704 -
Gingival Crevicular Fluid Levels Of Monocyte Chemoattractant Protein-1
|
N/A | |
Active, not recruiting |
NCT04051255 -
Influence of Smoking on Clinical, Microbiological and Immunologic Parameters in Patients With Aggressive Periodontitis.
|
N/A | |
Completed |
NCT05001919 -
Concentrated Growth Factors in Treatment of Intrabony Defects in Localized Aggressive Periodontitis
|
Phase 1/Phase 2 | |
Completed |
NCT03727620 -
Doxycycline in the Treatment of Aggressive Periodontitis
|
Phase 1/Phase 2 | |
Completed |
NCT04223869 -
IL-34 Levels in Various Types of Periodontitis
|
N/A | |
Completed |
NCT03034824 -
Effects of Er,Cr:YSGG, Diode Lasers on GCF Cytokines Levels
|
N/A | |
Completed |
NCT02049008 -
Treatment of Aggressive Periodontitis With Repeated Adjunctive Antimicrobial Photodynamic Therapy
|
Phase 4 | |
Recruiting |
NCT01510808 -
The Affect of Orthodontic Treatment on the Periodontal Status of Patients With Aggressive Periodontitis
|
N/A |