Aggressive Periodontitis Clinical Trial
Official title:
Evaluation of Gingival Crevicular Fluid Interleukin-1β and Interleukin-17 Levels and Periodontal Pathogens After Full-Mouth Disinfection Initial Periodontal Treatment in Generalized Aggressive Periodontitis Patients
Verified date | May 2020 |
Source | Marmara University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The purpose of this study is to determine whether full-mouth disinfection is effective in the
initial periodontal treatment of generalized aggressive periodontitis on clinical parameters,
gingival crevicular fluid interleukin-1β (IL-1β) and interleukin-17 (IL-17) and periodontal
pathogen levels compared with conventional initial periodontal treatment and full-mouth
initial periodontal treatment.
The investigators' hypothesis is to test whether full-mouth disinfection in the initial
periodontal treatment of generalized aggressive periodontitis enhance the clinical,
biochemical and microbiological parameters in comparison to conventional initial periodontal
treatment and full-mouth initial periodontal treatment.
Status | Completed |
Enrollment | 42 |
Est. completion date | September 2014 |
Est. primary completion date | September 2014 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 35 Years |
Eligibility |
Inclusion Criteria: - No systemic diseases that could influence the outcome of the therapy - No smoking - No medications affecting periodontal tissues - No pregnancy or lactation - Presence of at least 15 teeth Exclusion Criteria: - Received antibiotic treatment in the previous 3 months - Smokers - Pregnancy and lactation - Received periodontal treatment in the previous 6 months - Presence of less than 15 teeth - Presence of systemic diseases |
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
Marmara University |
Aimetti M, Romano F, Guzzi N, Carnevale G. Full-mouth disinfection and systemic antimicrobial therapy in generalized aggressive periodontitis: a randomized, placebo-controlled trial. J Clin Periodontol. 2012 Mar;39(3):284-94. doi: 10.1111/j.1600-051X.2011.01795.x. Epub 2012 Jan 4. — View Citation
de Lima Oliveira AP, de Faveri M, Gursky LC, Mestnik MJ, Feres M, Haffajee AD, Socransky SS, Teles RP. Effects of periodontal therapy on GCF cytokines in generalized aggressive periodontitis subjects. J Clin Periodontol. 2012 Mar;39(3):295-302. doi: 10.1111/j.1600-051X.2011.01817.x. Epub 2011 Nov 30. — View Citation
Mongardini C, van Steenberghe D, Dekeyser C, Quirynen M. One stage full- versus partial-mouth disinfection in the treatment of chronic adult or generalized early-onset periodontitis. I. Long-term clinical observations. J Periodontol. 1999 Jun;70(6):632-45. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Probing Depth | 6 months after initial periodontal treatment | ||
Secondary | Gingival Crevicular Fluid Interleukin-1ß and Interleukin-17 Levels (pg) | Baseline, 3 and 6 months after initial periodontal treatment | ||
Secondary | Level of A. Actinomycetemcomitans | Baseline, 3 and 6 months after initial periodontal treatment | ||
Secondary | Level of Porphyromonas Gingivalis | Baseline, 3 and 6 months after initial periodontal treatment | ||
Secondary | Level of Fusobacterium Nucleatum | Baseline, 3 and 6 months after initial periodontal treatment | ||
Secondary | Level of Parvimonas Micra | Baseline, 3 and 6 months after initial periodontal treatment | ||
Secondary | Bleeding on Probing | Possible score for BOP range from %0 (no sites with bleeding on probing) to %100 (all sites with bleeding on probing). Higher scores mean worse outcome. | Baseline, 3 and 6 months after initial periodontal treatment | |
Secondary | Plaque Index | Possible scores for Plaque Index range from 0 (no plaque) to 3 (visible plaque all around the tooth). Higher scores mean a worse outcome | Baseline, 3 and 6 months after initial periodontal treatment | |
Secondary | Gingival Index | Possible score for Gingival Index range from 0 (healthy gingiva) to 3 (severe gingivitis with bleeding). Higher scores mean worse outcome | Baseline, 3 and 6 months after initial periodontal treatment | |
Secondary | Clinical Attachment Level | Baseline, 3 and 6 months after initial periodontal treatment | ||
Secondary | Level of Prevotella Intermedia | Baseline, 3 and 6 months after initial periodontal treatment | ||
Secondary | Level of Campylobacter Rectus | Baseline, 3 and 6 months after initial periodontal treatment |
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