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Aggressive Periodontitis clinical trials

View clinical trials related to Aggressive Periodontitis.

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NCT ID: NCT05975892 Enrolling by invitation - Clinical trials for Aggressive Periodontitis

Transplantation of Bone Marrow Mesenchymal Stromal Cells for Periodontal Regeneration

BMMSC
Start date: August 30, 2018
Phase: Phase 1/Phase 2
Study type: Interventional

The goal of this study is to evaluate the capacity of allogeneic bone marrow mesenchymal stromal cells (MSC) to induce bone regeneration in patients with periodontal disease. MSC cultured are loaded on a collagen scaffold, included into autologous platelet rich plasma clot and implanted in the bone defect.

NCT ID: NCT05655338 Completed - Clinical trials for Aggressive Periodontitis

Antimicrobial Photodynamic Therapy in Treatment of Aggressive Periodontitis (Stage III, Grade C Periodontitis)

Start date: January 10, 2015
Phase: N/A
Study type: Interventional

Treatment of aggressive periodontitis (stage III, grade C periodontitis) represents a big challenge. The aim of the study was to compare the long-term results of antimicrobial photodynamic therapy (aPDT) and antibiotic therapy as an adjunct to conventional non-surgical therapy in patients with aggressive periodontitis. Clinical parameters of probing depth, clinical attachment level and bleeding on probing (BOP) were assessed at baseline, 3, 6, 9 and 12 months after treatment.

NCT ID: NCT05297084 Completed - Clinical trials for Aggressive Periodontitis

Non Surgical Periodontal Treatment Effect on Il-17 and Il-18 in Aggressive Periodontitis

Start date: March 27, 2021
Phase:
Study type: Observational

clinical parameters and IL-17 and Il-18 GCF levels were measured in 25 aggressive periodontitis patients compared to 25 periodontally healthy individuals. It was observed that that Clinical parameters and Il-17 and Il-18 levels are higher before treatment but decreased after treatment which suggests role of these interleukins in pathogenesis of aggressive periodontitis .

NCT ID: NCT05295576 Completed - Clinical trials for Aggressive Periodontitis

Effect of Non Surgical Periodontal Therapy on Inflammatory Markers in Chronic Periodontitis Patients

Start date: March 27, 2021
Phase:
Study type: Observational

The current study was performed to study levels of Il-17 and Il-18 in aggressive periodontitis patients before and after non surgical periodontal therapy

NCT ID: NCT05112471 Completed - Periodontitis Clinical Trials

Efficacy of GBT vs SRP+US, in the Treatment of Severe Generalized Periodontitis.

ERISRP
Start date: November 22, 2016
Phase: N/A
Study type: Interventional

The first step in the management of periodontal disease involves the non-surgical removal of the soft and hard bacterial deposits at all supra- and sub-gingival sites, especially into deep pockets, which can be carried on with different instruments. Unfortunately it seems that, after the initial therapy, many patients still present with active pockets (residual pockets) requiring further treatment and posing a risk of disease progression. This might be due to limitations of the instruments applied and patient-related factors. Air-polishing with low-abrasiveness powders seems to be very effective in the removal of supra- and sub-gingival biofilm and could provide additional benefits during the treatment of pockets. The aim of this randomized, controlled, split-mouth study was to compare the efficacy of full-mouth air-polishing followed by ultrasonic debridement (GBT) versus traditional Scaling and Root Planing (SRP), in terms of pocket closure in patients with stage III-IV periodontitis. To test this hypothesis, the mouth of each patients, upon initial evaluation, were divided in 2 parts: 1. The control group undergoing a standard procedure: ultrasonic debridement with an ultrasonic scaler for remove supra and sub gingival calculus, manual debridement with curettes at deep pathological pockets (PPD > 4mm) and rubber cup with polishing to remove supra gingival biofilm and plaque. 2. The study group undergoing the innovative air polishing procedure: airflow with erythritol powder to remove supra and sub gingival biofilm and plaque, perioflow at deep pathological pockets (PPD > 4mm) and ultrasonic debridement with an ultrasonic scaler for remove supra and sub gingival calculus. The prevalence of residual pockets will be evaluated at 6 weeks and 3 months after the initial therapy and compared between the two groups.

NCT ID: NCT05108727 Completed - Clinical trials for Periodontal Diseases

Diode Laser With Periodontal Flap Surgery in Periodontitis

Start date: January 2013
Phase: N/A
Study type: Interventional

The authors theorize that periodontal flap surgery therapy with adjunctive DL therapy might bring favourable therapy results (clinical and bacterial parameters) in patients with stage 3-grade C periodontitis. Therefore, the goal of this split-mouth randomized clinical trial was to evaluate and compare the effectiveness of the treatment results for DL assisted modified Widman Flap (MWF) surgery (test site) with MWF surgery alone (control site) in periodontitis patients with stage 3-grade C by determining the changes in clinical parameters and bacterial load of pathogens (P.g., T.d., Camplyobacter rectus (C.r.), Prevotella intermedia (P.i.), T.f., A.a.) at preoperative and following MWF surgery at 6th week, 3rd and 6th months

NCT ID: NCT05043935 Recruiting - Clinical trials for Aggressive Periodontitis

The Effect of Leukocyte and Platelet-rich Fibrin With Antimicrobial Photodynamic Therapy in Aggressive Periodontitis

Start date: November 22, 2021
Phase: N/A
Study type: Interventional

Antimicrobial photodynamic therapy (aPDT) is associated with photosensitizing agents which promote the generation of free radicals and singlet oxygen, which are cytotoxic to certain bacteria. Leukocyte and platelet-rich fibrin (L-PRF) has been used extensively in the treatment of intrabony defects and achieved excellent results. It acts as an immune regulation node with inflammation control abilities, including a slow continuous release of growth factors which stimulates periodontal regeneration. The aim of this study is to evaluate the adjunctive effects of aPDT with and without L-PRF in aggressive periodontitis patients.

NCT ID: NCT05001919 Completed - Clinical trials for Aggressive Periodontitis

Concentrated Growth Factors in Treatment of Intrabony Defects in Localized Aggressive Periodontitis

RCT
Start date: July 1, 2020
Phase: Phase 1/Phase 2
Study type: Interventional

A total of 20 intra-bony defects in 10 LAP patients were randomly assigned into two groups 10 defects each in a split-mouth design. Group I treated by surgery plus Bio-Oss bone graft + collagen membrane (Control group). Group II, treated by surgery plus Bio-Oss bone graft + CGF membrane (Test group). Gingival index (GI), bleeding on probing (BOP), probing pocket depth and clinical attachment level (CAL) were assessed at baseline, 3, 6, and 12 months. Cone beam radiograph evaluation was taken at baseline, and 12 months after surgery..

NCT ID: NCT04984031 Completed - Clinical trials for Molar-incisor Pattern Grade C Periodontitis ( Localized Aggressive Periodontitis)

Apoptosis Markers in Aggressive Periodontitis

Start date: August 5, 2021
Phase:
Study type: Observational

The aim of the present trial is to assess the gingival crevicular fluid level of caspase-3 and apoptosis inducing factor (AIF) in Generalized versus Molar-incisor grade C periodontitis. The present study will be carried out on patients selected from those attending on the outpatient clinics of Department of Oral Medicine, Periodontology, Oral Diagnosis and Dental Radiology, Faculty of Dental Medicine, Al-Azhar University, Assiut.

NCT ID: NCT04722380 Active, not recruiting - Clinical trials for Localized Aggressive Periodontitis

Nigella Sativa Oil Extract and Xenograft Bone Graft in Treatment of Infra-bony Defects

Start date: October 1, 2020
Phase: Phase 2
Study type: Interventional

The aim of this study will be to evaluate, clinically, and radiographically the effect of Nigella Sativa oil extract Mixed with xenograft versus xenograft alone in the treatment of intra-bony defects in patients with aggressive periodontitis.