Aged Clinical Trial - Immunologic Changes & Recovery-related Factors in

Status Completed

Clinical Trial Summary

Colorectal cancer is one of the most frequent malignancies, with a rising proportion of elderly patients in an aging society. In this study, the investigators attempted to find out the relationship between immunologic factors and recovery using various parameters impacting the treatment in elderly patients.

Clinical Trial Description

In prospective study, total 75 patients who received radical resection for colon cancer between September 2023 and February 2024 at Asan Medical Center was involved. Investigators included colon cancer patients treated with surgery, diagnosed with adenocarcinoma histologically and having information regarding preoperative status with abdominopelvic CT. Routine blood sampling and Immunologic tests including interleukin-6 (IL-6) and natural killer cell (NK cell) were performed at preoperative day, post operative 3rd day (POD#3), and outpatient clinic day (about postoperative 21th day (POD#21)). Investigators attempted to assess the patients' subjective health level using a simple questionnaire, EuroQol group- 5 dimension- 3 level (EQ-5D-3L). The sarcopenia was evaluated by the artificial intelligence software system and defined as an SMI < 41cm2/m2 in women and SMI < 43 cm2/m2 in men with a body mass index (BMI) < 25kg/m2, and < 53 cm2/m2 in men with a BMI ≥ 25 kg/m2. In this study, primary end point was recovery represented by hospital stay defined as the day from operation to discharge and readmission within 30days after discharge. Secondary end point was EQ-5D-3L (only in prospective cohort). 'Recovery' was evaluated by hospital stay and readmission within 30 days after discharge. Analyses of clinicopathological characteristics of categorical variables and continuous variables were conducted using the chi-square test and t-test, respectively. A multivariable analysis with Cox proportional hazards model was used to compare risk factors associated with postoperative hospital day including NLR, AGR, albumin, BMI and sarcopenia. Investigators conducted an analysis including variables that have been proven to be related to the immune system or recovery in previous studies or that are suspected to be clinically relevant. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT06454071
Study type	Interventional
Source	Soonchunhyang University Hospital
Contact
Status	Completed
Phase	Phase 2
Start date	September 4, 2023
Completion date	May 29, 2024

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT03297567` - Physical Therapy Guidelines For Hospitalized Elderly	N/A
Completed	`NCT00404118` - Senior Coordinated Referral Study	N/A
Not yet recruiting	`NCT04419753` - The Role of Attention Focus Walking Training in Older Adults.	N/A
Completed	`NCT03138265` - HIT Training in the Frail Elderly.	N/A
Completed	`NCT02598882` - Virtual Reality as a Tool for Rehabilitation on Elderly People	N/A
Completed	`NCT02598115` - Impact of Collaborative Pharmaceutical Care on Hospital Admission Drug Prescriptions for Patients 65 Years of Age and Older	N/A
Completed	`NCT05447533` - Clostridioides Difficile and Frailty	N/A
Completed	`NCT04127539` - Evaluation of Strong & Steady - Fall Preventive Group Exercise Program	N/A
Completed	`NCT05586828` - A Single-center Retrospective Cohort Study to Explore the Prognostic Significance of CONUT in Elderly CAD Patients With HFpEFand Compare CONUT With Other Objective Nutritional Indices.
Not yet recruiting	`NCT04516174` - Effect of Transversus Abdominis Plane Block Combined With Dexmedetomidine Infusion on the Prognosis in Elderly Patients Undergoing Abdominal Surgery	N/A
Completed	`NCT04536324` - The Absorption Rate of Subcutaneous Infused Fluid
Completed	`NCT02918058` - Reducing Post-discharge Potentially Inappropriate Medications Among Older Adults	N/A
Suspended	`NCT05107947` - Light in Frail Elderly - the Effect of a Dynamic Light for Sleep and Circadian Rhythm	N/A
Completed	`NCT03336177` - Understanding Low Gynecological Cancer Delay and Help-seeking Behavior in Older Patients.
Completed	`NCT06095661` - Virtual Reality as a Postoperative Pain Management Adjunct in Older Adults: An Acceptability and Feasibility Study	N/A
Completed	`NCT04715971` - Urinary Retention on an Acute Geriatric Hospitalisation Unit.
Recruiting	`NCT04327115` - Study of an Physical Exercise Program on Older People of 75 Years Old and More, Hospitalized in Geriatric Short Stay	N/A
Recruiting	`NCT04128410` - A Study on Central Transport Characteristics of Flurbiprofen Axetil in Elderly Patients
Completed	`NCT02253199` - The Effect of Age on the Median Effective Dose (ED50) of Intranasal Dexmedetomidine for Rescue Sedation Following Failed Sedation With Oral Chloral Hydrate During Magnetic Resonance Imaging	Phase 4
Completed	`NCT02280928` - Development and Evaluation of a Home-Based Dual-Task Training Program to Improve Balance Performance for Older Adults	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Immunologic Changes and Recovery-related Factors in Elderly Colon Cancer Patients

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms