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NCT05875623 Clinical Trial

Impact of Medications Review on Potentially Inappropriate Medications and Clinical Outcomes Among Hospitalized Older Adults

Aged Clinical Trial

Official title:
Impact of Medications Review on Potentially Inappropriate Medications and Clinical Outcomes Among Hospitalized Older Adults: A Randomized Controlled Trial (REVMED RCT) Protocol

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT05875623
Other study ID # REVMED RCT
Secondary ID
Status Recruiting
Phase N/A
First received
Last updated
Start date July 6, 2023
Est. completion date June 2025

Study information
Verified date October 2023
Source Monash University
Contact Chee Tao Chang, Msc
Phone +6052085000
Email chee.chang@monash.edu
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

The goal of this randomized controlled trial is to assess the effectiveness of a pharmacist-led medication review using the locally developed Malaysian Potentially Inappropriate Prescribing Screening tool in Older Adults (MALPIP), an explicit criteria in hospitalized older adults. The main questions it aims to answer are: 1. The effectiveness of the intervention in reducing the number of PIMs and chronic medications after discharge 2. The impact of the intervention on quality of life, falls events, emergency department visits, readmissions and survivals Researchers will compare the control group to see if there is corresponding changes to the outcomes specified above.

Recruitment information / eligibility
Status Recruiting
Enrollment 500
Est. completion date June 2025
Est. primary completion date February 2025
Accepts healthy volunteers No
Gender All
Age group 60 Years and older
Eligibility Inclusion Criteria: - Patients aged 60 years and above - Taking more than five regular drugs - Having at least one chronic medical condition - Ability to understand and speak Malay, English, or Mandarin language Exclusion Criteria: - Admitted for end-of-life care - Diagnosed with terminal illness - Diagnosed with active cancer - Participated in another drug trial - Refused or unable to give consent - Visited the Emergency Department without admission to ward - Readmitted and have been previously enrolled in the trial

Study Design

Related Conditions & MeSH terms

Intervention

Other:
• MALPIP criteria
In the intervention group, the clinical pharmacist will apply the MALPIP criteria on all the admission and discharge medications. The intervention will consist of 4 steps: i) pharmacist review using MALPIP criteria to detect PIM, ii) discussion with doctors for deprescribing decision iii) discussion with patients and documentation of shared decision iv) follow up patients

Locations
Country Name City State
Malaysia Shaun Lee Subang Jaya Selangor

Sponsors (2)
Lead Sponsor Collaborator
Monash University Hospital Raja Permaisuri Bainun

Country where clinical trial is conducted

Malaysia, 

Outcome
Type Measure Description Time frame Safety issue
Primary Number of potentially inappropriate medications Admission up to 18 months
Primary Number of chronic medications Admission up to 18 months
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