Retinol-induced Dermatitis in Aged Skin

Aged Skin Clinical Trial

Official title:
Molecular Analyses of Retinoid-induced Dermatitis in Aged/Photoaged Human Skin

Status Completed

Clinical Trial Summary

Topical therapy with retinoids is the only proven medical therapy for aged/photoaged human skin. However, topical therapy with retinoids often result in unwanted cutaneous dermatitis, including erythema and scaling. The reseachers intend to investigate the dose, frequency of use, and time dependence of topical retinol-induced dermatitis. The researchers intend to evaluate retinoid-induced dermatitis biochemically, including retinol regulation of retinoid responsive genes that control retinoid metabolism and serve as markers for retinoid bioactivity. The researchers will also investigate the role of EGF receptor pathway in retinoid-induced dermatitis.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00857610
Study type	Observational
Source	University of Michigan
Contact
Status	Completed
Phase
Start date	July 20, 2009
Completion date	August 29, 2014

View Details

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