Multimodal Imaging of Retinal Vessels

Age-Related Macular Degeneration Clinical Trial

— MIR  

Official title:

Retinal Vessel Morphology in Multimodal Imaging

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02717026
• Other study ID #: 27-262ex14/15
• Status: Completed
• Start date: July 2015
• Est. completion date: January 2018

Study information

• Verified date: September 2020
• Source: Medical University of Graz
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Retinal blood flow measurement is of scientific and clinical value. For this purpose retinal vessel morphology (such as diameter, vessel wall thickness, etc) determination is crucial. Different imaging modalities might provide divergent results. Thus, quantification of such differences is valuable.

The present study aims to reveal and quantify differences in vessel morphology between fundus photography, fundus angiography, and optical coherence tomography in health and disease.

Description:

This is considered a pilot study and will pe performed on patients scheduled for routine fluorescein angiography.

During the study day the following procedures will be performed:

• Medical history and concomitant medication

• Blood pressure and heart rate

• Assessment of visual acuity using Snellen vision charts

• Biomicroscopy

• Intraocular pressure

• Funduscopy

• IOL-Master axial length measurement

• Fundusphotography

• Optical coherence tomography

• Fluorescein Angiography Fundus photography analysis will be performed with an automated software and analysis of both angiography and optical coherence tomography will be performed via the devices inbuilt software.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 50
• Est. completion date: January 2018
• Est. primary completion date: December 2017
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• written informed consent, clear media

Exclusion Criteria:

• any abnormality preventing reliable vessel measurement, pregnancy,

Related Conditions & MeSH terms

• Age-Related Macular Degeneration
• Macular Degeneration
• Retinal Blood Vessels

Intervention

Device:
• Optical coherence tomography
Sections including the retinal vasculature will be taken.
• Fluorescein angiography
Video fluorescein angiography from one eye of each subject will be performed
• Fundus photography
30 and 50 degree fundus images

Locations

Country	Name	City	State
Austria	Department of Ophthalmology, Medical University of Graz	Graz	Styria

Sponsors (1)

Lead Sponsor	Collaborator
Medical University of Graz

Country where clinical trial is conducted

Austria, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	retinal vessel diameter		5 minutes
Secondary	retinal vessel reflectivity		5 minutes