Age-related Macular Degeneration Clinical Trial
Official title:
A 12-month, Phase IIIb, Randomized, Visual Acuity Assessor-masked, Multicenter Study Assessing the Efficacy and Safety of Ranibizumab 0.5mg in Treat and Extend Regimen Compared to Monthly Regimen, in Patients With Neovascular AMD
This study is designed to evaluate the efficacy and safety of two different regimens of 0.5 mg ranibizumab given as intravitreal injection in patients with neovascular age-related macular degeneration
This is a 12-month, phase IIIb, randomized, Visual Acuity assessor-masked, multi-center,
interventional study assessing the efficacy and safety of the TER vs monthly regimens of 0.5
mg ranibizumab intravitreal (IVT) injections in patients with newly diagnosed nAMD. Patients
will be randomized 1:1 into one of two treatment arms, Treat and Extend or monthly regimens.
There will be 3 periods in this study: Screening period (up to 14days), treatment period (11
months), follow-up period (1 month). At randomization visit patients will be randomized into
one of the 2 treatment groups Group I ranibizumab 0.5 mg based on monthly treatment or Group
II ranibizumab 0.5 mg based on TER (randomization ratio of 1:1) and will receive the first
dose of Investigational treatment. Patients in Group I the following visits will perform on
monthly intervals. For patients in Group II the investigator will evaluate disease activity
(i.e., signs of exudation) based on SD-OCT, and in case of absence of disease activity every
next visit will be 2 weeks), with a maximum of a 12-week interval.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Supportive Care
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