Clinical Trials Logo

Clinical Trial Summary

The purpose of this study is to determine if the menopausal transition is associated with subjective and objective cognitive declines that ameliorate in menopause. The investigators hypothesize that perimenopause is associated with both subjective memory complaints and objective declines in attentionally mediated cognitive tasks. The investigators also hypothesize that this is time-limited. The investigators predict that as women transition from early perimenopause to late perimenopause their performance on attentionally mediated and verbal memory tasks will decline, and that as they transition from late perimenopause to menopause, their performance will improve.


Clinical Trial Description

Two groups of women will be recruited, those in early perimenopause and those in mid to late perimenopause. Tests of attention, working memory, mental flexibility, processing speed, and retentive memory will be administered to each subject at 6 month intervals for 5 years. Additionally, women will be asked to fill out questionnaires about their mood, memory functioning, health, and quality of life. The investigators will also calculate each subject's Body Mass Index (BMI) and waist circumference at each visit. Finally, serum levels of reproductive hormones will be taken. Measures of interest will be the percentage of women in each group with absolute and relative cognitive deficits, change over time in performance on neuropsychological tests and scores on depression and anxiety scales, and correlations between cognitive function, mood and hormone level. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT01429103
Study type Observational
Source University of Rochester
Contact
Status Completed
Phase N/A
Start date May 2011
Completion date November 2016

See also
  Status Clinical Trial Phase
Completed NCT01711008 - The Effect of Breakfast Size Prior to Morning Exercise on Cognition, Mood and Appetite in Habitually Active Women N/A
Not yet recruiting NCT05468684 - PROCO Neck: The Course and Neuroplasticity in Neck Pain-Associated Disorders and Whiplash-Associated Disorders
Recruiting NCT02891343 - Effect of Hypoxia on Cognitive Assessment and Cerebral Activity in Healthy Volunteers N/A
Completed NCT02486328 - The Effect of Different Sedation Regimes on Cognitive Function in Lower Gastrointestinal System Endoscopy Phase 4
Active, not recruiting NCT01877967 - Investigating the Effect of Dietary Supplement VSL#3 on Cognition and Mood in Healthy Older Adults N/A
Completed NCT02300272 - Health Behaviors and Time-of-Day: Older Adult Cognitive Function
Completed NCT02270320 - Cognitive Effects of Tai Chi Chuan in Healthy Older Adults and Older Adults N/A
Completed NCT01012947 - Cognitive Health Promotion Project in the Community Phase 1
Recruiting NCT02792985 - Multisensory Stimulation and Enriched Environments During Post-traumatic Amnesia N/A
Completed NCT02958735 - Exercise and Cognition Trials N/A
Completed NCT01555996 - Early Occupational Therapy for Delirium Prevention in Older Patients Admitted to Critical Care Unit N/A
Completed NCT02884050 - Physiologic Effects of Topiramate on Cognition Phase 1
Completed NCT02847793 - Attentional Bias Modification Through Eye-tracker Methodology (ABMET) N/A