Affective Disorder Clinical Trial
Official title:
Clinical Psychopharmacology Division
The project is a multi-center, prospective cohort study. The study's total targeted enrollment is 400 first-episode patients with major depressive disorder (MDD) and 400 healthy controls.
Four hundred patients with a primary diagnosis of depression and HAMD-17 scores ≥14 at baseline visit are to be assigned to one of the second-generation antidepressant drugs, including escitalopram, duloxetine, mirtazapine, paroxetine, sertraline, etc based on investigators' clinical practice. Initial treatment consists of a 8-week course with one of these monotherapies. Patients who meet criteria for full remission are followed for a 22-month follow-up phase to monitor for depression recurrence. Patients who do not remit are offered another 8 weeks of acute treatment, including combination therapy or switching to other antidepressant based on investigators' clinical practice. The clinical assessment (Hamilton Depression Rating Scale(HAMD)/ Clinical general impression (CGI) /the Positive and Negative Affect Schedule (PANAS) /subtypes of depression, Dimensional Anhedonia Rating Scale (DARS) , etc), early life stress, neuropsychological test, and biological examination (MRI, genetics, neurochemistry, and immunology) were conducted to identify the biomarkers associated with diagnosis, treatment efficacy prediction of depression. Among the 400 patients, about 100 patients receive MRI scans at baseline and after treatment. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Active, not recruiting |
NCT04136054 -
Better Sleep in Psychiatric Care - Anxiety and Affective Disorders
|
N/A | |
| Recruiting |
NCT05461885 -
Value of Gym-based Exercise Training for Young Adults Receiving Antipsychotic Medication: The Vega Trial
|
N/A | |
| Completed |
NCT01721824 -
The Effect of IPS-MA- A Modified Early Supported Employment Intervention for Individuals With Mood or Anxiety Disorders
|
N/A | |
| Recruiting |
NCT05869409 -
Physical Activity, Psychopathology, and Quality of Life in People With Psychotic or Affective Disorders
|
||
| Active, not recruiting |
NCT05249309 -
Naturalistic Study of Ketamine in the Treatment of Depression
|
||
| Completed |
NCT03235908 -
Copeptin in Outcome Prediction of an Acute Psychotic Episode
|
||
| Not yet recruiting |
NCT04288609 -
Effectiveness of a Cognitive Remediation Intervention Based on Virtual Reality for Promotion of Cognitive Functioning and Participation in Daily Life Among Persons With Affective Disorder
|
N/A | |
| Completed |
NCT04489641 -
Brief Group Psychotherapy for Anxiety and Depression
|
N/A | |
| Recruiting |
NCT05596461 -
New Techniques for Diagnosis and Treatment of Cognitive Impairment in Affective Disorder
|
N/A | |
| Completed |
NCT03609515 -
Patient-controlled Admissions in Inpatient Mental Health Services
|
N/A |