Feasibility Clinical Trial
Official title:
Photodynamic Therapy Using a Novel Photosensitizer in Locally Advanced Hilar Cholangiocarcinoma
To determine the safety and efficacy of photodynamic therapy with a novel photosensitizer and a flexible laser probe in locally advanced hilar cholangiocarcinoma.
Photodynamic therapy (PDT) is a way of producing tissue necrosis with light after prior
administration of a photosensitizing agent. The most important advantages include the
possibility of combining PDT with other target therapies and repeat the process as needed
with a favorable outcomes. The combination of diverse therapeutic modalities is one of the
new strategies to enhance oncologic treatments for pancreatic cancer. In order to overcome
the limitations of each treatment modalities and to prevent the development of resistance,
the application of PDT combined with target therapies, without increasing the toxicity for
the patient, is being widely investigated.
PDT has been only extensively studied for the treatment of various superficial skin cancers
in the Europe but not available in the United States and Japan due to the overlapping
treatment fields. In Korea, the use of first-generation and second-generation
photosensitizers are part of the study of Gastroenterology, Dermatology, Otolaryngology, and
Gynecology.
Recently, although the investigators have introduced PDT using novel photosensitizers has
not yet been used for the treatment of pancreatic cancers. This study aim to determine the
safety and efficacy of photodynamic therapy with a novel photosensitizer in locally advanced
hilar cholangiocarcinoma.
;
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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