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Clinical Trial Summary

Patients meeting eligibility criteria will be randomized into two groups, one receiving pharmacogenetic testing and the other not receiving pharmacogenetic testing. In this open-label trial, a pharmacist will make medication therapy recommendations using YouScript® Personalized Prescribing System for patients who receive genetic testing and standard drug information resources per usual for patients who do not undergo pharmacogenetic testing.


Clinical Trial Description

Both groups will be followed for 60 days. The number of re-hospitalizations and emergency department (ED) visits will be recorded as well as time to first re-hospitalization and time to first ED visit. Select Outcome and Assessment Information Set (OASIS) metrics (e.g. M1034, M1242, M1710, M1720, M1745, M2110) and Patient Health Questionnaire (PHQ)-2 will be evaluated and documented at time of admission to home health, at 30 days, and at 60 days for improvement in overall status, pain, confusion, anxiety, depression, disruptive behavior, and the need for assistance with activities of daily living (ADLs) and instrumental activities of daily living (IADLs). The number of falls will be collected as well as the proportion of YouScript® recommendations accepted by study pharmacist and passed on to clinicians and the proportion of recommendations accepted by clinicians. ;


Study Design


Related Conditions & MeSH terms

  • Adverse Drug Events
  • Adverse Drug Reactions
  • Cytochrome P450 CYP2C19 Enzyme Deficiency
  • Cytochrome P450 CYP2C9 Enzyme Deficiency
  • Cytochrome P450 CYP2D6 Enzyme Deficiency
  • Cytochrome P450 CYP3A Enzyme Deficiency
  • Cytochrome P450 Enzyme Deficiency
  • Drug Interaction Potentiation
  • Drug Metabolism, Poor, CYP2C19-RELATED
  • Drug Metabolism, Poor, CYP2D6-RELATED
  • Drug-Related Side Effects and Adverse Reactions
  • Poor Metabolizer Due to Cytochrome p450 CYP2C19 Variant
  • Poor Metabolizer Due to Cytochrome P450 CYP2C9 Variant
  • Poor Metabolizer Due to Cytochrome P450 CYP2D6 Variant

NCT number NCT02378220
Study type Interventional
Source Genelex Corporation
Contact
Status Completed
Phase N/A
Start date March 2015
Completion date March 2016

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