Clinical Trials Logo
  1. Home
  2. Adverse Drug Events
  3. NCT02026453

Pharmacists and Pharmacy Technicians to Improve Admission Medication History Accuracy

Adverse Drug Events Clinical Trial

Official title:
Pharmacists and Pharmacy Technicians to Improve Admission Medication History Accuracy

Clinical Trial Summary

We tested two interventions to improve the accuracy of medication histories obtained at hospital admission. The interventions target elderly and chronically ill patients prone to erroneous medication histories and resultant medication errors. For targeted patients, we tested the effect of using pharmacists and pharmacy technicians to obtain an initial medication history. This was studied using a randomized controlled trial of usual care (which involves nurses and physicians) vs usual care + pharmacists vs usual care + pharmacy technicians to obtain an admission medication history.

The overarching hypothesis was that by leveraging pharmacists and pharmacy technicians we can minimize admission medication history errors and related downstream events.

Clinical Trial Description

Importance: Admission medication history (AMH) errors frequently cause medication order errors and patient harm.

Objective: To quantify AMH error reduction achieved when pharmacy staff obtain AMHs before admission medication orders (AMO) are placed.

Design: Three-arm randomized clinical trial. Setting: Large hospital with community and trainee physicians. Population: 306 enrolled patients with complex medical histories. Interventions: In one intervention arm, pharmacists, and in the second intervention arm, pharmacy technicians obtained initial AMHs prior to admission. They obtained and reconciled medication information from multiple sources. All arms, including the control arm, received usual AMH care. This included common process variation occurring in: accuracy of pre-existing medication histories; nurses' ability to obtain AMHs at hospital admission; and admitting physicians' efforts to verify and order from prior AMHs.

Main Outcomes and Measures: The primary outcome was severity-weighted mean AMH error score. To detect AMH errors, all patients received reference standard AMHs, which were compared with intervention and control group AMHs. AMH errors and resultant AMO errors were independently identified and rated by ≥2 investigators as significant, serious or life-threatening. Each error was assigned 1, 4 or 9 points, respectively, to calculate severity-weighted AMH and AMO error scores for each patient. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02026453
Study type Interventional
Source Cedars-Sinai Medical Center
Contact
Status Completed
Phase N/A
Start date January 2014
Completion date October 2016
View Details
See also
  Status Clinical Trial Phase
Completed NCT02239237 - Post-marketing Safety Surveillance of Compound Kuh-seng Injection: a Registry Study
Completed NCT01179867 - Using Novel Canadian Resources to Improve Medication Reconciliation at Discharge N/A
Completed NCT02191358 - YouScript IMPACT Registry N/A
Completed NCT02059044 - Information Systems-enabled Outreach Program for Adverse Drug Events N/A
Completed NCT01164137 - Eliminating Risk of Preventable Adverse Drug Events at the Hospital-community Interface of Care N/A
Completed NCT02482025 - The Secure Messaging for Medication Reconciliation Tool (SMMRT) Trial N/A
Completed NCT04692220 - Drug-Related Problems : Focus on Age and Diabetes
Completed NCT02378220 - Pharmacogenetic Testing Among Home Health Patients N/A
Completed NCT01337063 - Multi-Center Medication Reconciliation Quality Improvement Study N/A
Completed NCT02593916 - Response to Medication Registry
Completed NCT00013143 - Patient Profiling and Provider Feedback to Reduce Adverse Drug Events N/A
Withdrawn NCT00606606 - Reducing Adverse Drug Events in the Nursing Home N/A
Completed NCT02805270 - Impact of Medication Reconciliation Intervention on the Rate of Preventable Adverse Drug Events (ADEs) and Healthcare Utilization N/A
Completed NCT01764204 - Hospital Intensive Monitoring of Adverse Drug Reactions of Qingkailing Injection In The Next Two Years N/A
Completed NCT01531088 - Enhancing the Detection and Management of Adverse Drug Events in Nursing Homes N/A
Completed NCT02122965 - The Effect of Medication Review in High-risk Emergency Department Patients N/A
Completed NCT00780572 - Implementation of Real-time ADE Surveillance and Decision Support N/A
Completed NCT01091038 - Improving Safety by Basic Computerizing Outpatient Prescribing Phase 2/Phase 3
Recruiting NCT04479553 - Post-marketing Safety Surveillance of Qizhi Tongluo Capsules:a Registry Study.
Active, not recruiting NCT00740675 - Ambulatory Medication Reconciliation Following Hospital Discharge N/A