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Clinical Trial Summary

This study incluces a phase I study to evaluate the tolerance, safety, pharmacokinetic characteristics and preliminary efficacy of PM1022 in patients with advanced tumors and a phase IIa study to investigate the efficacy of PM1022 in patients with advanced tumors.


Clinical Trial Description

PM1022 is a recombinant humanized anti-PDL1 and anti-TIGIT bispecific antibody. This Phase 1/2, multicenter, first-in-human, open-label, dose-escalation, dose expansion, and clinical expansion study will evaluate the safety, tolerability, pharmacokinetics, and preliminary anti-tumor efficacy of PM1022 administered as a single-agent by IV infusion every 3 weeks to patients with locally advanced or metastatic solid malignancies, who have failed or are intolerant to standard therapy, or for whom no standard therapy is available. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05867771
Study type Interventional
Source Biotheus Inc.
Contact Ye Guo
Phone +86 13501678472
Email Pattrickguo@gmail.com
Status Recruiting
Phase Phase 1/Phase 2
Start date April 11, 2022
Completion date April 10, 2025

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