Advanced Solid Tumours Clinical Trial
Official title:
A Phase Ib, Dose Finding Study Evaluating AZD1775 in Monotherapy, in Combination With Carboplatin and Paclitaxel, and in Combination With Only Carboplatin in Adult Asian Patients With Advanced Solid Tumours
This is a phase Ib, open-label, multicentre study of AZD1775 administered orally in monotherapy and in combination with carboplatin and paclitaxel to Asian patients with advanced solid tumours.
This is a phase Ib, open label, multicentre study of AZD1775 administered orally in monotherapy and in combination with carboplatin and paclitaxel in Asian patients with advanced solid tumours. The study design allows escalation or de-escalation of AZD1775 in combination with carboplatin and paclitaxel with intensive safety monitoring to ensure the safety of the patients. Approximately 12 evaluable patients will be enrolled in the dose-finding portion of this study. The total number of patients will depend upon the number of combination dose level evaluations necessary to define the recommended dose for further clinical evaluation. The proposed combination doses are : Dose level-1; Dose level 1; Dose level 2 (if Dose Level 1 tolerated). All combination doses other than Combination Dose level 1 may be subject to change by the SRC in light of emerging data. At least 3 and up to 6 evaluable patients will be required for each dose finding cohort. Once the recommended dose for further clinical evaluation is established, additional 3 to 6 patients may be enrolled to the cohort where the recommended dose has been defined to further characterise the safety, tolerability, pharmacokinetics, and efficacy profiles of AZD1775 in combination with paclitaxel and carboplatin. If this dose is subsequently found to be non-tolerated, alternative doses and/or schedules may be explored. This will be determined by the SRC. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Active, not recruiting |
NCT05514132 -
A Study to Evaluate the Safety and Pharmacokinetics of Ceralasertib in Combination With Durvalumab in Chinese Patients With Advanced Solid Tumours
|
Phase 1 | |
| Terminated |
NCT04949425 -
A Study to Assess the Safety and Tolerability of Adavosertib for Patients With Advanced Solid Tumours
|
Phase 1 | |
| Not yet recruiting |
NCT05537051 -
A Study of PM1021 (Anti-TIGIT) With or Without PM8001 (Anti-PD-L1/TGF-β) in Patients With Advanced Solid Tumours
|
Phase 1 | |
| Completed |
NCT02579226 -
A Phase I Study of Safety, Tolerability, and PK of AZD2811 in Patients With Advanced Solid Tumors.
|
Phase 1 | |
| Terminated |
NCT01668550 -
A Phase I Study of AZD0424 Alone and in Combination in Advanced Solid Tumours
|
Phase 1 | |
| Completed |
NCT01058538 -
A Dose Finding Pharmacokinetic Study of the Tumour-targeting Human L19IL2 Monoclonal Antibody-Cytokine Fusion Protein in Patients With Advanced Solid Tumours
|
Phase 1/Phase 2 | |
| Completed |
NCT02588105 -
Study to Assess the Safety and Preliminary Efficacy of AZD0156 at Increasing Doses Alone or in Combination With Other Anti-cancer Treatment in Patients With Advanced Cancer
|
Phase 1 | |
| Recruiting |
NCT03852823 -
Study of Recombinant Human Anti-PD-1 Monoclonal Antibody in Patients With Advanced Tumours
|
Phase 1 | |
| Not yet recruiting |
NCT06380816 -
A Phase I/II Trial of UCB4594 in Participants With Advanced Cancer
|
Phase 1/Phase 2 | |
| Completed |
NCT01585701 -
Phase I Study of AT13148, a Novel AGC Kinase Inhibitor
|
Phase 1 | |
| Completed |
NCT03101839 -
Phase I Dose-Escalation Study of AZD4785 in Patients With Advanced Solid Tumours
|
Phase 1 | |
| Completed |
NCT03150368 -
Extended Use of ModraDoc006/r
|
Phase 1 | |
| Active, not recruiting |
NCT02389842 -
PIPA: Combination of PI3 Kinase Inhibitors and PAlbociclib
|
Phase 1 | |
| Terminated |
NCT01581060 -
Phase I/II Dose-escalation Study to Investigate Safety and Pharmacokinetics/ Pharmacodynamics of WX-554 in Patients With Solid Tumours
|
Phase 1/Phase 2 | |
| Terminated |
NCT04959266 -
A Study to Assess the Effects of Itraconazole, Rifampicin, and Omeprazole on Pharmacokinetics of Adavosertib
|
Phase 1 | |
| Completed |
NCT04462952 -
Study of Adavosertib(AZD1775) in Japanese Patients With Advanced Solid Tumours
|
Phase 1 | |
| Active, not recruiting |
NCT03518606 -
Metronomic Oral Vinorelbine Plus Anti-PD-L1/Anti-CTLA4 ImmunothErapy in Patients With Advanced Solid Tumours
|
Phase 1/Phase 2 | |
| Completed |
NCT02430311 -
The Pharmacokinetics and Safety of Olaparib Alone and With Paclitaxel in Chinese Patients With Advanced Solid Tumour.
|
Phase 1 | |
| Terminated |
NCT01859351 -
Phase I Study of WX-037 Alone and in Combination With WX-554 in Solid Tumours
|
Phase 1 | |
| Completed |
NCT01163903 -
Pantoprazole With Doxorubicin for Advanced Cancer Patients With Extension Cohort of Patients With Solid Tumours
|
Phase 1 |