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Clinical Trial Summary

This is a prospective, multicenter, single arm clinical study. The main purpose of the study is to evaluate the clinical efficacy and safety of SBRT combined with Nimotuzumab and mono-chemotherapy in the treatment of locally advanced pancreatic cancer (LAPC).


Clinical Trial Description

This clinical study is designed as a prospective, multicenter, single arm study to evaluate the clinical efficacy and safety of SBRT combined with nimotuzumab and mono-chemotherapy in the treatment of locally advanced pancreatic cancer (LAPC). All eligible patients will receive SBRT with doses ranging from 35-40 Gy in five fractions, intravenous nimotuzumab 400mg weekly or 600mg on day 1 and 8 of a 21-day cycle, and mono-chemotherapy (Gemcitabine, S-1 or capecitabine) until disease progression, death, unacceptable toxicity, or consent withdrawal. The main endpoint is progression-free survival (PFS). ;


Study Design


Related Conditions & MeSH terms


NCT number NCT06422156
Study type Interventional
Source Peking University Third Hospital
Contact Bin Qiu, MD
Phone +86 010-82265968
Email qiubin@pku.edu.cn
Status Not yet recruiting
Phase Phase 2
Start date June 1, 2024
Completion date June 1, 2026

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