Advanced or Metastatic NSCLC Clinical Trial
Official title:
Elderly Cancer PatIents Treated for Advanced or Metastatic Melanoma or NSCLC, Safety and qualiTy of Life Under immunOtheraPies: a Phase IV Trial
The co-primary objectives will be to assess the safety and quality of life under treatment.
The co-primary objectives will be to assess the safety and quality of life under treatment.
Secondary objectives will be evaluations of geriatric data modifications under treatment,
efficacy (progression-free survival and overall survival), correlation between toxicity and
efficacy, and comparison of the safety profiles between various immunotherapy regimens.
Another secondary objective will be the comparison between patients and clinicians symptom
reporting. The investigators will also perform a pharmacokinetics analysis on PD1-monoclonal
antibodies to improve the understanding of PD-1 inhibitors pharmacokinetics for the elderly
population.
Finally, toxicity and efficacy will be compared to immunological parameters such as the
description of tumor infiltrating lymphocytes, markers of immunosenescence and inflammation.
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|---|---|---|---|
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