| Eligibility |
Inclusion Criteria:
1. Voluntarily signed informed consent form; good compliance during the whole study;
2. Histologically or cytologically confirmed diagnosis of unresectable advanced or
metastatic CRC, not including appendix and anal canal cancer;
3. patients failed or intolerable to previous standard second-line treatment for locally
advanced or metastatic CRC;
4. Patients who have not received previous bevacizumab therapy can be treated in
combination with bevacizumab;
5. Patients who did not receive chemotherapy, radiotherapy, surgical therapy, molecularly
targeted drug therapy 4 weeks prior to enrollment, with no plan for concurrent other
chemotherapy and surgery;
6. Age 18 -70 years old, ECOG performance status of 0-2; Life expectancy= 3 months;
7. Patients must have at least one measurable target lesion with long axis =10 mm on CT
or MRI, with short axis =15mm for lymph node based on RECIST 1.1, within 4 weeks
before enrolment;
8. Seven days prior to treatment, haematology test should meet the following requirements
(no treatment with G-CSF or TPO 14 days before test): HGB =90 g/L, ANC =1.5×109/L, PLT
=100×109/L, WBC =3.0×109/L bilirubin =1.5×ULN, aspartate transaminase (AST)/ alanine
transaminase (ALT) =2.5 ×ULN (patients with liver metastasis =5xULN), and creatinine
clearance =50 mL/min;
9. Peripheral neuropathy (PN) =grade 1 on the Common Terminology Criteria for Adverse
Events (CTCAE) version 4.03 within 4 weeks before enrolment; patients with any grade
of alopecia are eligible for enrolment;
10. Patients with no major organ dysfunctions and heart disease;
11. Women and men of childbearing potential must agree to take effective contraceptive
measures during the study and within six months after the last treatment. Female
patients must have negative urinary pregnancy test within 7 days before the first
treatmment (postmenopausal women must have no menstruation for at least 12 months
before they are considered unable to conceive);
12. Patients must agree to provide blood samples for specific biomarkers study;
13. No other concurrent investigational agents during the study.
Exclusion Criteria:
1. Patients having history of other malignancies except CRC within the last five years,
but patients with fully recovered in situ cervix carcinoma or non-melanoma skin cancer
are eligible;
2. No other anticancer therapies, such as chemotherapy, hormonal therapy, immunotherapy,
antibody therapy and radiotherapy, or concurrent other chemotherapy during treatment;
3. Patients with uncontrollable brain metastasis, uncontrollable bone metastasis or
recent risk of fracture;
4. Arterial or venous thrombosis or embolic events such as cerebrovascular accident
(including TIA), deep venous thrombosis or pulmonary embolism occurred within one
year;
5. history of symptomatic heart disease (including unstable angina, myocardial infarction
and heart failure);
6. history of interstitial lung disease (ILD), such as interstitial pneumonia, pulmonary
fibrosis, or evidence of ILD on baseline chest CT or MRI;
7. Patients with gastrointestinal bleeding, active gastrointestinal ulcer or
gastrointestinal obstruction (including paralytic intestinal obstruction). Patients
with gastrointestinal perforation or gastrointestinal fistula and abdominal abscess
within 6 month;
8. Previous partial or total gastrectomy, or major operations (such as laparotomy,
thoracotomy and intestinal resection) within 4 weeks;
9. Patients with AEs caused by any previous treatment (including systemic and local
treatment) that have not yet restored to GRADE 1 (excluding hair loss);
10. Patients who are pregnanct (positive pregnancy test), breastfeeding or unwilling to
take contraceptive measures during the trial;
11. active or uncontrollable infections requiring systemic treatment (except simple
urinary or upper respiratory infections) within 2 weeks;
12. Severely allergic to Cremophor or having severe adverse events associated with
paclitaxel in the past;
13. Patients with active pulmonary tuberculosis.Patients having obvious cough blood or
hemoptysis of half a teaspoon (2.5 ml) or more during the last one month;
14. Existence of uncontrolled diabetes, hypertension, active or uncontrollable infections;
15. Patients with serous effusion (such as pleural effusion, pericardial effusion and
ascites) with clinical symptoms requiring intervention or stabilization for less than
4 weeks;
16. Patients with radiology findings that tumors have invaded important perivascular areas
or tumors that are highly likely to invade important blood vessels during treatments
which may lead to fatal massive hemorrhage determined by investigators;
17. Patients with abnormal coagulation function and tendency to bleed;
18. Patients with known HIV infection or untreated active hepatitis B or C;
19. Patients with alcohol or drug addiction, or a history of uncontrollable mental
illness, lack of or limited legal capacity;
20. Patients with other conditions determined by investigators that may affect compliance
with study protocol and study evaluation and are not suitable for participating in the
study.
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