Clinical Trial Details
— Status: Completed
Administrative data
NCT number |
NCT05852002 |
Other study ID # |
HSHN004 |
Secondary ID |
|
Status |
Completed |
Phase |
N/A
|
First received |
|
Last updated |
|
Start date |
April 11, 2023 |
Est. completion date |
December 12, 2023 |
Study information
Verified date |
April 2023 |
Source |
Nakhia Impex LLC |
Contact |
n/a |
Is FDA regulated |
No |
Health authority |
|
Study type |
Interventional
|
Clinical Trial Summary
In this research, the patients with advanced lung cancer accompanied by pain and discomfort
were treated by injecting freshly manufactured tissue permeable hyaluronan fragment HA35 into
the tissue under abdominal adipose.
Description:
Pain is generally considered the most common symptom of lung cancer. The three most common
causes of pain in patients with advanced lung cancer are: 1. metastasis of lung cancer to the
bones, which accounts for approximately 34 percent of lung cancer pain; 2. Presence of a
Pancoast tumor, located at the top of the lung close to the brachial plexus nerves and
cervical sympathetic nerves, which accounts for approximately 31 percent of lung cancer pain;
3. Spread of the cancer into the chest wall, accounting for approximately 21 percent of lung
cancer pain.
Palliative care is a specialized field that aims to alleviate symptoms and maximize the
patient's quality of life. Palliative care does not focus on curing the disease or prolonging
life, which is the goal of other cancer treatments, such as chemotherapy. However, palliative
care is an important part of the patient's treatment plan and encompasses physical symptoms,
psychosocial distress, spiritual distress, and caregiver distress.
The management of pain due to lung cancer may include a combination of medications, such as
non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids, opioids (pain medications),
and antidepressants. For metastases to the bone, radiation therapy and the use of
bisphosphonates (drugs to help prevent bone breakdown) can alleviate pain. In addition,
smoking cessation (stopping smoking) is recommended, as surveys have revealed that lung
cancer patients who continue to smoke after diagnosis have a higher incidence of pain and
other lung cancer complications than nonsmokers and those who quit smoking.
While pain is the most common symptom of lung cancer, other symptoms include: persistent
coughing,wheezing,shortness of breath,hoarseness,weight loss,loss of appetite,fatigue or
feeling weak and respiratory infections (like bronchitis or pneumonia) that don't go away or
keep returning.
Hyaluronidase PH20 produced 35 kDa tissue permeable low molecular weight hyaluronan fragment
by cutting high molecular hyaluronan. The previous clinical studies had shown that local
injection of 35 kDa hyaluronan fragment effectively relieved inflammatory pain and
neuropathic pain and promoted chronic wound healing.