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Clinical Trial Summary

This is a phase II study to determine the efficacy and safety of Pembrolizumab when given in combination with Lenvatinib as treatment for patients with the advanced kidney cancer. Further evaluate whether the treatment plan is beneficial to the patient's operation. Patients will receive treatment with Pembrolizumab in combination with Lenvatinib every 3 weeks for 3 cycles pre-operation and patients need to continue taking the drug for a year after surgery.


Clinical Trial Description

This is a phase II study to determine the efficacy and safety of Pembrolizumab when given in combination with Lenvatinib as treatment for patients with the advanced kidney cancer . Further evaluate whether the treatment plan is beneficial to the patient's operation.Patients will receive treatment with Pembrolizumab in combination with Lenvatinib every 3 weeks for 3 cycles pre-operation and patients need to continue taking the drug for a year after surgery. The main objective of the study was to evaluate whether the treatment was beneficial to patients undergoing surgery. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05485896
Study type Interventional
Source Tianjin Medical University Second Hospital
Contact Changyi Quan, MD,PhD
Phone 13388067990
Email 345920147@qq.com
Status Recruiting
Phase Phase 2
Start date July 1, 2022
Completion date December 31, 2024

See also
  Status Clinical Trial Phase
Recruiting NCT05485883 - Tislelizumab Plus Lenvatinib in Stage III-IV RCC Phase 2
Active, not recruiting NCT03308396 - Study of Durvalumab and Guadecitabine in Advanced Kidney Cancer Phase 1/Phase 2
Withdrawn NCT03540199 - Study of Activated Cytokine-induced Killer Armed With Bispecific Antibody for Advanced Kidney Cancer Phase 2