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First-line Apatinib Combined With Tislelizumab and Chemotherapy for Advanced GC — RENMIN-213  

Advanced Gastric Adenocarcinoma Clinical Trial

Official title:
First-line Apatinib Combined With Tislelizumab and Chemotherapy for Advanced Gastric and Gastroesophageal Junction(G/GEJ) Adenocarcinoma Patients With Poor Prognosis: A Prospective Exploratory Study

Clinical Trial Summary

In this clinical study, investigators explore the efficacy and safety of a combination therapy regimen with antiangiogenic agent (apatinib), ICI (tislelizumab), and chemotherapy (capecitabine+ Oxaliplatin, XELOX) as first-line treatment for HER2-negative, advanced G/GEJ cancer patients with signet ring cell carcinoma or peritoneal metastasis.

Clinical Trial Description

Patients received 8 cycles of apatinib (250 mg, qd, d1-14), tislelizumab (200 mg d1), and oxaliplatin (130 mg/m2, d1) plus oral capecitabine (1000 mg/m2, bid, d1-14) every 3 weeks, with a maintenance therapy with apatinib plus tislelizumab for a maximum of 1 year. Homogeneous patients receiving ICIs combined with chemotherapy at the same time were deemed as the control group for efficacy. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06238752
Study type Interventional
Source Renmin Hospital of Wuhan University
Contact
Status Completed
Phase Phase 2
Start date March 1, 2021
Completion date January 1, 2024
View Details
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