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Study of Amblyomin-X in Advanced Solid Tumor — Amblyomin-X  

Advanced Cancer Clinical Trial

Official title:
Phase I Study (First in Humans) of the Amblyomin-X in the Treatment of Patients With Advanced Solid Tumors Refractory or Without Indication / Access to Standard Treatment

Clinical Trial Summary

Amblyomin-X is an inhibitor of Factor Xa that also acts as an apoptotic agent for tumor cells. In the case of in vitro assays, Amblyomin-X induces tumor cells to death and does not affect the viability of normal cells. When in vivo assays were performed on mice bearing tumors, treatment with Amblyomin-X caused a significant reduction in tumor mass and number of metastases.

Clinical Trial Description

This trial will be the first clinical study in humans with the product, which until then has been studied only in experimental models. Given the current epidemiological impact of cancer and the need to improve its systemic treatment, making it available to a larger portion of the Brazilian population, it is proposed to conduct the first Amblyomin-X study in cancer patients, more specifically those with advanced solid tumors For which there is no contraindicated or inaccessible therapeutic option established as the standard at the time of inclusion in the study. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03120130
Study type Interventional
Source União Química Farmacêutica Nacional S/A
Contact
Status Suspended
Phase Phase 1
Start date February 15, 2021
Completion date May 22, 2022
View Details
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