Advanced Cancer Clinical Trial
Official title:
A Phase I Study of Anlotinib on Tolerance and Pharmacokinetics
Anlotibib (ALTN) is a kind of innovative medicines approved by State Food and Drug
Administration（SFDA） which was researched by Jiangsu Chia-tai Tianqing Pharmaceutical Co.,
Ltd.
ALTN is a kinase inhibitor of receptor tyrosine with multi-targets, especially for VEGFR2
and VEGFR3. It has the obvious resistance to new angiogenesis.
The primary objective of this trial is to explore the maximum tolerated dose(MTD), dose-limiting toxicity(DLT) of ALTN and rational dosage regimen for phase II study, to investigate the pharmacokinetics with single and multiple doses of ALTN from 5mg/d,10mg/d,16mg/d,12mg. ;
Endpoint Classification: Pharmacokinetics/Dynamics Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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