Clinical Trial Details
— Status: Completed
Administrative data
| NCT number |
NCT01143779 |
| Other study ID # |
2009-0658 |
| Secondary ID |
|
| Status |
Completed |
| Phase |
Phase 1
|
| First received |
|
| Last updated |
|
| Start date |
June 2010 |
| Est. completion date |
December 27, 2021 |
Study information
| Verified date |
January 2022 |
| Source |
M.D. Anderson Cancer Center |
| Contact |
n/a |
| Is FDA regulated |
No |
| Health authority |
|
| Study type |
Interventional
|
Clinical Trial Summary
The goal of this clinical research study is to learn if an imaging solution,
[F-18]-fluoro-L-thymidine (FLT), when used with a positron emission tomography (PET) scan,
can help doctors to better see changes in the growth of tumors in the body. Researchers want
to learn if FLT-PET scans can show an early response to chemotherapy.
Description:
FLT-PET Scan:
An FLT-PET scan uses the FLT solution, which contains a small amount of radioactive material,
to help locate cancer cells inside the body. This scan may help doctors find solid tumors as
well as learn if these tumors are growing and how fast they are growing. This information
could be used to help predict if the cancer will respond to treatment.
Study Visits:
Within 2 weeks before Day 1 of Cycle 1 and between Days 19 and 21 of Cycle 1, you will have a
FLT-PET scan.
For at least 4 hours before the FLT-PET scan, you must not eat or drink anything. You will
receive the FLT solution by vein. The FLT solution is a mildly radioactive material. The
radioactive nature of the solution allows the scanner to "see" it in certain places in your
body. After the injection, you will need to rest quietly until it is time for the scan. The
amount of rest time may vary, but be prepared to wait for about 60 minutes. During the scan,
you will lie flat on your back on a table. After the solution is injected into a vein, the
PET scanner takes pictures of the radioactive solution as it moves through the body and
collects at various sites in the body. By watching how the solution travels through the body
and studying where the solution collects, researchers can learn the status of disease in the
body. The scan itself may last about 40-60 minutes.
Your vital signs (blood pressure, heart rate, temperature, and breathing rate) will be
measured before each injection of the FLT solution, 30 minutes after each injection, and
before each PET scan. You will be allowed to leave 30 minutes after your scan, if your vital
signs are acceptable.
Length of Study:
You will be off this study after the second FLT-PET scan. You will be taken off study early
if you have intolerable side effects or the study doctor thinks it is in your best interest.
This is an investigational study. The FLT solution is not FDA approved or commercially
available. At this time, FLT solution is only being used in research.
Up to 5 patients will take part in this study. All will be enrolled at MD Anderson.
