Clinical Trials Logo

Clinical Trial Summary

The objective of this study is to evaluate the efficacy and safety of oncolytic virotherapy combined with Tislelizumab plus lenvatinib in patients with advanced biliary tract cancer (BTC).


Clinical Trial Description

Recent studies have suggested that local destruction of tumor tissue by oncolytic virus induced activation and maturation of dendritic cells and tumor-specific T cells by cross-presentation of tumor antigens. While pd-1 blocking antibody interferes with PD-1 mediated T-cell regulatory signaling. And combination of pd-1 blocking antibody plus lenvatinib showed increased ORR in many type of human cancers. Therefore, the objective of this study is to evaluate the efficacy and safety of oncolytic virotherapy combined with Tislelizumab plus lenvatinib in patients with advanced BTC. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05823987
Study type Interventional
Source Fudan University
Contact Peng Wang
Phone 86-21-64175590
Email wangp413@163.com
Status Recruiting
Phase Phase 2
Start date May 16, 2023
Completion date December 30, 2025

See also
  Status Clinical Trial Phase
Not yet recruiting NCT05009953 - Study of Irinotecan Liposome Injection in Patients With Advanced Biliary Tract Cancer Phase 2
Recruiting NCT05820906 - Cadonilimab Plus Regorafenib and Gem-Cis Chemotherapy in Advanced Biliary Tract Cancer Phase 2
Completed NCT03358849 - Phase 1 Clinical Trial to Evaluate the Safety of Allogeneic NK Cell ("SMT-NK") Cell Therapy in Advanced Biliary Tract Cancer Phase 1
Recruiting NCT05410197 - Envofolimab and Lenvatinib Combined With Gemcitabine Plus Cisplatin for Advanced BTC as First-Line Treatment(ENLIGHTEN) Phase 2
Active, not recruiting NCT04727996 - Phase II Study of Sitravatinib in Combination With Tislelizumab in Patients With Advanced Biliary Tract Cancer Phase 2
Not yet recruiting NCT04733521 - A Phase 1/2 Study of SC-43 in Combination With Cisplatin Phase 1/Phase 2
Recruiting NCT04027764 - Toripalimab Combined With S1 and Albumin Paclitaxel in Patients With Advanced Biliary Tract Cancer Phase 2
Recruiting NCT05781074 - Cryoablation Combined With Sintilimab Plus Lenvatinib in Patients With Immune Checkpoint Inhibitor Previously Treated Advanced Biliary Tract Cancer (CASTLE-08) Phase 2
Recruiting NCT04781192 - The Purpose of This Trial is to Determine if Regorafenib Plus Durvalumab (MEDI4736) is Safe and Effective in Treatment of Chemo Refractory Advanced Biliary Tract Cancers Phase 1/Phase 2
Recruiting NCT05653180 - IBI310 in Combination With Sintilimab in Patients With Advanced Biliary Tract Cancer Phase 1/Phase 2
Recruiting NCT04005339 - NAPOLI-2: Fluorouracil, Leucovorin, and Nanoliposomal Irinotecan in Biliary Cancer Phase 2
Completed NCT04217954 - HAIC With Oxaliplatin, 5-FU and Bevacizumab Plus Intravenous Toripalimab for Advanced BTC Phase 2
Recruiting NCT05170438 - Lenvatinib Plus Paclitaxel for Patients With Advanced Biliary Tract Cancer Who Failed to Gemcitabine-based Treatment Phase 2
Active, not recruiting NCT04172402 - NGS as the First-line Treatment in Advanced Biliary Tract Cancer Phase 2
Withdrawn NCT02597465 - A Randomized, Open-Label, Comparative, Parallel-Group, Multicenter Study of SPARC1507 Phase 3
Active, not recruiting NCT04969887 - Combination Immunotherapy in Rare Cancers Under InvesTigation Phase 2
Recruiting NCT04211168 - Toripalimab Plus Lenvatinib as Second-line Treatment in Advanced Biliary Tract Cancers Phase 2
Recruiting NCT05812430 - Anlotinib Plus TQB2450 Combined With Nab-paclitaxel and Cisplatin as First-line Treatment for Advanced Biliary Tract Cancer Phase 2