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Advanced Biliary Tract Cancer clinical trials

View clinical trials related to Advanced Biliary Tract Cancer.

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NCT ID: NCT04969887 Active, not recruiting - Clinical trials for Neuroendocrine Tumors

Combination Immunotherapy in Rare Cancers Under InvesTigation

MOST-CIRCUIT
Start date: August 3, 2021
Phase: Phase 2
Study type: Interventional

The four tumour streams that will be studied in this protocol are based on immunotherapy sensitive rare cancers from CA209-538 which will be further investigated under this protocol and divided into four groups: 1. Neuroendocrine cancers: Atypical bronchial carcinoid, neuroendocrine carcinoma and Grade 3 NETs independent of primary site (SCLC excluded) 2. Biliary tract cancers: Intrahepatic cholangiocarcinoma and gallbladder carcinoma 3. Gynaecological malignancies: Ovarian clear cell carcinoma, uterine clear cell carcinoma, uterine/ovarian carcinosarcoma, uterine leiomyosarcoma and vaginal/vulva squamous cell carcinoma 4. Mismatch repair protein deficient (MSI-H) cancers (excluding colorectal carcinoma). The role of immunotherapy is being defined in more common cancer types, however because of their rarity, the efficacy of immunotherapy for these cancers is poorly defined. This protocol provides an important opportunity to establish whether the combination of nivolumab & ipilimumab has efficacy in these cancers.

NCT ID: NCT04727996 Active, not recruiting - Clinical trials for Advanced Biliary Tract Cancer

Phase II Study of Sitravatinib in Combination With Tislelizumab in Patients With Advanced Biliary Tract Cancer

BTC-BGB
Start date: November 1, 2020
Phase: Phase 2
Study type: Interventional

This is open-label, phase II study enrolling advanced BTC patients who have failed to 1st-line chemotherapy.

NCT ID: NCT04172402 Active, not recruiting - Clinical trials for Advanced Biliary Tract Cancer

NGS as the First-line Treatment in Advanced Biliary Tract Cancer

Start date: December 27, 2019
Phase: Phase 2
Study type: Interventional

To evaluate disease objective response rate (ORR) of nivolumab in combination with gemcitabine and TS1 in patients with advanced biliary tract cancer