Adults Clinical Trial
Official title:
Cranial Electrotherapy Stimulation: Piloting a Road to PTSD Prevention in First Responders
The goal of this study is to test whether active duty firefighters find it possible and suitable to do cranial electrotherapy stimulation (CES) at home, and test whether CES influences measures of stress. The main questions it aims to answer are: - is CES feasible and acceptable in a population of firefighters, and - does CES changes feelings of fatigue, anxiety, and brain connectivity in firefighters. Participants will - complete four weeks of CES at home, and - complete daily assessments of fatigue and anxiety, and maybe asked to - complete an MRI scan before and after CES, and - wear a device to measure their heart rate and sleep quality.
Despite an urgent need for interventions that can prevent the development of posttraumatic stress disorder (PTSD) in firefighter first responders who, due to the nature of their occupation, are at ultrahigh risk for PTSD and its profound consequences, current preventative approaches suffer from low rates of efficacy or difficulties with implementation. Cranial electrotherapy stimulation (CES), a noninvasive brain stimulation technique that is FDA approved for treatment of anxiety, insomnia, and depression, offers substantial promise as a proactive preventative intervention for PTSD because of its hypothesized ability to reestablish homeostasis, a process that becomes dysregulated in individuals who develop PTSD. The proposed study is an administrative supplement that combines the unique strengths and knowledge of a complimentary team of scientists from two distinct Centers of Biomedical Research Excellence to test whether four weeks of CES is feasible and acceptable in firefighters as well as obtain early signal of CES efficacy to change subjective and objective indices of homeostatic functioning to allow a long-term collaboration with the ultimate goal to develop a safe, effective, and easily deployable intervention to prevent PTSD in first responders. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT04704726 -
Examining Essentialistic Beliefs About Food
|
||
Active, not recruiting |
NCT06042218 -
Xiaxi Program for Back Health
|
N/A | |
Not yet recruiting |
NCT06054542 -
Turkish Version of Digital Eye Strain Questionnaire (DESQ)
|
||
Completed |
NCT03582943 -
Effects of RLIC on Motor Learning in Middle-aged and Older Adults
|
Phase 1 | |
Recruiting |
NCT06086145 -
Biomarker-estimated Flavanol Intake in Davis (FID)
|
||
Completed |
NCT04589221 -
Sensory and Oral Processing Characteristics of Commonly Consumed Foods
|
||
Completed |
NCT01995838 -
A Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group, Bayesian Adaptive Randomization Design, Dose Response Study of the Efficacy of E2006 in Adults and Elderly Subjects With Chronic Insomnia
|
Phase 2 | |
Completed |
NCT05071170 -
Satiety Responses and Oral Processing Characteristics of Commonly Consumed Meals
|
||
Completed |
NCT03962517 -
Effect of GEMS-H on Locomotor Function in Adults
|
N/A | |
Completed |
NCT04683432 -
The Texture, Eating Rate and Glycaemic Index (TERAGI) Study
|
||
Completed |
NCT04860349 -
Is High Intensity Interval Training Effective to Reduce the Waist Circumference and Fat Percentage at Trunk Region
|
N/A | |
Recruiting |
NCT04422782 -
New Tools for Predicting Capillary Leak Shock During Dengue Fever
|
N/A | |
Recruiting |
NCT04881292 -
RF Based QIMT & QAS Study on Chinese Adults
|
||
Not yet recruiting |
NCT04837170 -
Safety and Efficacy Evaluation of S (+) - Ketamine in Adults
|
Phase 4 | |
Completed |
NCT04058769 -
Software-guided Guideline Implementation in Premedication
|
N/A | |
Completed |
NCT05741047 -
Comparative Effects of a2 Skim Milk on Mild Cognitive Impairment in Older Adults
|
N/A | |
Active, not recruiting |
NCT02398825 -
Activity and Risk Profile of Ponatinib in Chronic Phase Patients With Chronic Myeloid Leukemia Resistant to Imatinib
|
Phase 2 | |
Completed |
NCT05460585 -
Cerebral Oxygenation Values in Healthy Adults Volunteers Measured With RheoPatch and NIRO-200NX
|
||
Completed |
NCT04843202 -
Clinical Guidelines in Premedication Visit
|
||
Completed |
NCT04522063 -
Variation in Food Intakes, Physical Activity, and Psychological Stress on Fluctuations in 24-hr Plasma Glucose Levels
|