Chondrosarcoma Clinical Trial
Official title:
S9624: Phase II Study of Ifosfamide in Patients With Aggressive Meningeal Tumors
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing
so they stop growing or die.
PURPOSE: Phase II trial to study the effectiveness of ifosfamide in treating patients with
meningeal tumors that have recurred or that cannot be removed surgically.
OBJECTIVES:
- Estimate failure free survival, overall survival, and response in patients with
residual or recurrent/progressive aggressive meningeal tumors (malignant meningioma,
hemangiopericytoma, and primary nervous system sarcoma) treated with ifosfamide.
- Evaluate toxicities of ifosfamide in this patient population.
OUTLINE: All patients receive ifosfamide IV continuously over 72 hours on days 1-3 of each
21 day treatment course. Patients are evaluated for response/progression after every 2
courses. Patients with stable disease receive up to 8 courses of therapy. Treatment
continues in the absence of disease progression or unacceptable toxicity.
Patients are followed every 3 months for 1 year, then every 6 months thereafter.
PROJECTED ACCRUAL: Approximately 35 patients will be accrued for this study.
;
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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