Evaluation of Adult Onset Still Disease Classification Criteria and Differential Diagnosis at Eighteen Months of Follow-up

Adult Onset Still Disease Clinical Trial

— AOSD-DIF  

Official title:

Evaluation of Adult Onset Still Disease Classification Criteria and Differential Diagnosis at Eighteen Months of Follow-up

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04750863
• Other study ID #: 2021PI001
• Status: Completed
• Start date: July 15, 2010
• Est. completion date: February 1, 2021

Study information

• Verified date: February 2021
• Source: Central Hospital, Nancy, France
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Adult Onset Still Disease (AOSD) is an acquired inflammatory disease of unknown etiology, presenting with non specific symptoms. Its diagnosis rely on sets of criteria, i.e. Fautrel Criteria and Yamaguchi Criteria. However, differential diagnosis might appear during follow-up of patients. The aim of this study is to assess diagnostic performance of Fautral and Yamaguchi Criteria after 18 months of follow-up, and to describe differential diagnosis appearing during follow-up.

Description:

Adult Onset Still Disease (AOSD) is an acquired inflammatory disease of unknown etiology, presenting with non specific symptoms. Other conditions such as cancer, infection or other inflammatory disease might mimick its symptoms. Its diagnosis rely on sets of criteria, i.e. Fautrel Criteria and Yamaguchi Criteria. However, differential diagnosis might appear during follow-up after an initial diagnosis of AOSD. The aim of this study is to assess diagnostic performance of Fautral and Yamaguchi Criteria after 18 months of follow-up, and to describe differential diagnosis appearing during follow-up.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 312
• Est. completion date: February 1, 2021
• Est. primary completion date: February 1, 2021
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• adults

• with glycosylated ferritin dosage for suspected adult onset still disease

• with at least 18 month of follow-up

Exclusion Criteria:

• known infectious disease

• known cancer

• known active connective tissue disease or vasculitis

Related Conditions & MeSH terms

• Adult Onset Still Disease
• Arthritis, Juvenile
• Still's Disease, Adult-Onset

Intervention

Other:
• diagnosis criteria performance

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Central Hospital, Nancy, France

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	diagnosis performance of Yamaguchi and Fautrel criteria at 18 months of follow-up	Sensitivity, Specificity, positive predictive value, negative predictive value	after 18 months of follow-up
Secondary	description of differential diagnosis mimicking adult onset still disease		after 18 months of follow-up
Secondary	identifying factors associated with the occurence of a differential diagnosis during follow-up		after 18 months of follow-up