Cediranib, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma

Adult Glioblastoma Clinical Trial

Official title:

A Phase Ib/II Study of AZD2171 in Combination With Daily Temozolomide and Radiation in Patients With Newly Diagnosed Glioblastoma Not Taking Enzyme-Inducing Anti-epileptic Drugs

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00662506
• Other study ID #: NCI-2009-00267
• Secondary ID: NCI-2009-00267MG
• Status: Completed
• Phase: Phase 1/Phase 2
• Start date: April 2008
• Est. completion date: April 2014

Study information

• Verified date: September 2017
• Source: National Cancer Institute (NCI)
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This phase I/II trial is studying the side effects and best dose of cediranib to see how well it works when given together with temozolomide and radiation therapy in treating patients with newly diagnosed glioblastoma. Cediranib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor. Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Radiation therapy uses high-energy x-rays to kill tumor cells. Giving cediranib together with temozolomide and radiation therapy may kill more tumor cells.

Description:

PRIMARY OBJECTIVES: I. To determine the safety profile and optimal dose of AZD2171 (cediranib) (15mg or 20mg or 30mg) in combination with temozolomide and radiation in patients with newly diagnosed glioblastoma (Phase Ib) II. To determine median progression-free survival of patients with newly diagnosed glioblastoma treated with AZD2171 in combination with temozolomide and radiation (Phase II) SECONDARY OBJECTIVES: I. To determine the radiographic response proportion in newly diagnosed glioblastoma patients with measurable disease. (Phase II) II. To determine the median overall survival. (Phase II) III. To determine the "vascular normalization" window in newly diagnosed glioblastoma patients by the application of serial, non-invasive, MRI parameters. (Phase II) IV. To measure the glucose metabolism changes in a subset of newly diagnosed glioblastoma patients by performing FDG PET studies. (Phase II) V. Measurement of circulating endothelial and progenitor cells and plasma levels of VEGF-A; VEGF-B; VEGF-C; VEGF-D; sVEGFR1, sVEGFR2, bFGF, PlGF, PDGF-AA; PDGF-AB; PDGF-BB; SDF1α; tumstatin; thrombospondin-1; interleukin-8; collagen IV sICAM1, sVCAM1 as markers for response to AZD2171 in newly diagnosed glioblastoma patients. (Phase II) VI. Correlation of treatment outcomes with pre-AZD2171 tumor specimens with respect to cell proliferation, apoptosis, microvascular density (MVD), basement membrane and pericyte coverage, angiopoietin-1 and -2 expression to determine whether these immunohistochemical analyses can be predictive of the response to AZD2171. (Phase II) OUTLINE: This is a phase I, dose-escalation study of cediranib followed by a phase II study. Patients begin study treatment within 21-42 days after craniotomy or 14-21 days after stereotactic biopsy. PHASE Ib: CHEMORADIOTHERAPY: Patients receive cediranib orally (PO) once daily and oral temozolomide once daily for 6 weeks. Within 2-6 hours of dosing, patients undergo concurrent intensity-modulated radiotherapy (IMRT) once daily, 5 days a week for 6 weeks. Cediranib monotherapy: Patients receive cediranib PO once daily for 4 weeks (weeks 7-10). Cediranib and temozolomide monthly therapy: Patients receive cediranib PO once daily for 24 weeks (weeks 11-34) and temozolomide once daily, 5 days a week in weeks 11, 15, 19, 23, 27, and 31. Cediranib monotherapy: Patients receive a fixed-dose of cediranib once daily for 24 weeks (weeks 35-58). PHASE II: CHEMORADIOTHERAPY: Patients receive cediranib PO at the recommended phase II dose determined in phase Ib, temozolomide PO, and undergo concurrent IMRT as in phase Ib (weeks 1-6). Cediranib monotherapy: Patients receive cediranib PO (at the recommended phase II dose determined in phase Ib) once daily for 4 weeks (weeks 7-10). Cediranib and temozolomide monthly therapy: Patients receive cediranib PO (at the recommended phase II dose determined in phase Ib) once daily for 24 weeks (weeks 11-34) and temozolomide once daily, 5 days a week in weeks 11, 15, 19, 23, 27, and 31. Cediranib monotherapy: Patients receive a fixed-dose of cediranib once daily for 24 weeks (weeks 35-58). Patients undergo blood and urine sample collection at baseline and periodically during study. Blood samples are measured for tumstatin, as well as other well established biomarkers, including VEGF-A, -D, sVEGFR1, sVEGFR2, sICAM1, sVCAM1, PlGF, PDGF-AA, PDGF-AB, PDGF-BB, thrombospondin-1, and IL-8 by electrochemiluminescence detection. Circulating endothelial cell (CEC) assays are evaluated to assess the kinetics of CECs and progenitor cells prior to and during antiangiogenic therapy with cediranib and chemoradiotherapy. Urine samples are collected for proteomic analyses to evaluate serial change of growth factors such as VEGF and PlGF and of matrix metalloproteinases in response to treatment with cediranib. Archival tumor tissue is collected for analysis of tumor microvascular density, basement membrane and pericyte coverage, angiopoietin-1 and -2 expression, tumor cell proliferation, and apoptosis by immunostaining methods and immunoenzyme techniques. Patients also undergo dynamic contrast enhanced (DCE)-MRI and T2-weighted or perfusion-weighted MRI at baseline and periodically during study to monitor antiangiogenic effect on tumor vasculature through parameters reflecting both tumor perfusion and permeability; and diffusion tensor imaging to measure degree of water diffusion and fractional anisotropy. A subset of patients undergo fludeoxyglucose F 18 positron emission tomography (FDG-PET) periodically to monitor antiangiogenic effects on glucose utilization. After completion of study treatment, patients are followed periodically for 1 year.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 46
• Est. completion date: April 2014
• Est. primary completion date: April 2014
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Histologically confirmed glioblastoma
• Newly diagnosed disease
• Scheduled to receive standard post-surgical (i.e., biopsy or resection) temozolomide and radiotherapy
• Must have residual, contrast-enhancing tumor (= 1 centimeter in = 1 dimension)
• Patients must be maintained on a stable corticosteroid regimen for 5 days prior to their baseline scan and for 5 days prior to their first vascular MRI; the dose of steroids should remain the same during the baseline vascular MRIs
• Archival tumor tissue available for molecular analysis
• No intratumoral hemorrhage or peritumoral hemorrhage by MRI
• Karnofsky performance status 60-100%
• Leukocytes = 3,000/mcl
• Absolute neutrophil count = 1,500/mcL
• Platelet count = 100,000/mcL
• Hemoglobin = 8 g/dL
• Total bilirubin normal
• AST/ALT = 2.5 times upper limit of normal
• Creatinine normal OR creatinine clearance = 60 mL/min
• Not pregnant or nursing
• Negative pregnancy test
• Fertile patients must use effective contraception
• Proteinuria = 1+ on two consecutive dipsticks = 7 days apart
• Mini-mental status examination score = 15
• Must be able to tolerate MRI and must consent to participate in additional Vascular Imaging Procedures per protocol
• CT scans cannot be substituted for MRI
• Mean QTc = 500 msec (with Bazett's correction) by electrocardiogram
• No concurrent malignancy except curatively treated basal cell or squamous cell carcinoma skin cancer or carcinoma in situ of the cervix or breast
• Patients with prior malignancies must be disease-free for = 5 years
• No history of familial long QT syndrome or other significant ECG abnormality
• No history of allergic reactions attributed to compounds of similar chemical or biologic composition to cediranib
• No uncontrolled intercurrent illness including, but not limited to, any of the

following:

• Hypertension (e.g., blood pressure > 140/90 mm Hg)
• Ongoing or active infection
• Symptomatic congestive heart failure
• Unstable angina pectoris
• Cardiac arrhythmia
• Psychiatric illness/social situations that would preclude study compliance
• No known coagulopathy that increases risk of bleeding
• No history of clinically significant hemorrhages in the past
• No New York Heart Association class III-IV heart disease
• No condition requiring concurrent drugs or biologics with proarrhythmic potential
• No other concurrent chemotherapy agents, investigational agents, or biologic therapy
• No prior chemotherapy, radiotherapy, or any experimental therapy for this disease
• No prior IV bevacizumab for any other medical condition
• No prior carmustine implant (Gliadel Wafer)
• No prior brachytherapy or radiosurgery for this disease
• More than 30 days since prior and no other concurrent investigational agents or participation in an investigational therapeutic trial
• At least 2 weeks since prior and no concurrent enzyme-inducing anti-epileptic drugs (EIAEDs)
• Concurrent non-EIAEDs allowed
• No concurrent CYP450-inducing anticonvulsants
• No concurrent anticoagulants (e.g., dalteparin, warfarin, or low-molecular weight heparin)
• If patients require warfarin or other anticoagulants (e.g., low-molecular weight heparin) while on study, then patient may continue treatment
• No concurrent combination antiretroviral therapy for HIV-positive patients
• No concurrent VEGF inhibitors
• No concurrent pentamidine
• No concurrent herbal or nontraditional medications

Related Conditions & MeSH terms

• Adult Giant Cell Glioblastoma
• Adult Glioblastoma
• Adult Gliosarcoma
• Glioblastoma
• Gliosarcoma

Intervention

Drug:
• Cediranib Maleate
Given PO

Procedure:
• Diffusion Tensor Imaging
Undergo DTI
• Diffusion Weighted Imaging
Undergo T1 weighted DCE-MRI
• Dynamic Contrast-Enhanced Magnetic Resonance Imaging
Undergo DCE-MRI

Radiation:
• Fludeoxyglucose F-18
Undergo 18 FDG PET
• Intensity-Modulated Radiation Therapy
Undergo IMRT

Other:
• Laboratory Biomarker Analysis
Correlative studies

Procedure:
• Perfusion Magnetic Resonance Imaging
Undergo PWI
• Positron Emission Tomography
Undergo 18 F FDG-PET

Drug:
• Temozolomide
Given PO

Locations

Country	Name	City	State
United States	Dana-Farber Cancer Institute	Boston	Massachusetts
United States	Massachusetts General Hospital Cancer Center	Boston	Massachusetts

Sponsors (1)

Lead Sponsor	Collaborator
National Cancer Institute (NCI)

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Progression-free survival (Phase II)	The fraction of patients alive and free of disease progression after the MRI scan scheduled. This fraction will be compared, using a one sample, two-sided exact binomial test, to 50% progression-free survival (PFS). For safety assessment, the study will be powered to ensure at least 85% chance of observing a serious adverse event, if the probability of such an event on treatment were >=5%.	At day 218
Primary	Safety profile and optimal dose of cediranib during chemoradiotherapy (Phase I)	A dose-limiting toxicity of cediranib is defined as a clinically significant adverse event or abnormal laboratory value assessed as unrelated to disease progression, intercurrent illness, or concomitant medications/temozolomide and occurs following the first dose of cediranib in the chemoradiation.	Up to 30 days after the last dose
Secondary	Blood biomarkers (Phase II)	Log-transformation is expected to yield approximately homogenous and symmetric standard errors, both for Poisson events and quantities obtained by assays with successive dilutions. We will plot the median levels and quartiles over time. First, we will compare on-study values to baseline, than we will test for an association between treatment time and markers, using a linear mixed effects model with log-transformed data and a spline function of time. The two-sided, paired t-test test will be powered to detect an effect-size of 0.5.	Up to 1 year
Secondary	MRI parameters (Phase II)	The comparisons of all MRI measurements will be against their day -1 values (baseline), using a 2-sided, paired Wilcoxon test (Hollander and Wolfe 1973).	Up to 48 weeks
Secondary	Tumor biomarkers (Phase II)	Exploratory analyses will be performed to determine if there is any correlation between the molecular/vascular phenotype of the tumor or quantitative measurements, we will use for this purpose ANOVA on log-transformed marker measurements. We will analyze changes in the measurements, and correlate biomarkers with clinical and radiographic response, similarly as for blood and urine biomarkers.	At baseline