Human Phenotype Project Study Protocol

Adult Disease Clinical Trial

Official title:

Longitudinal Collection of Observational Clinical and Lifestyle Data

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05817734
• Other study ID #: 1789-1
• Status: Recruiting
• Start date: October 1, 2018
• Est. completion date: December 31, 2045

Study information

• Verified date: April 2023
• Source: Weizmann Institute of Science
• Contact: Eran Segal, Prof.
• Phone: 972-8-9343266
• Email: Eran.Segal[@]weizmann.ac.il
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

This is a prospective study aimed at recruiting 30,000 individuals, aged 40-70 years old, and following them longitudinally for 25 years with repeated measurements. The basic follow-up frame will include a visit to the Clinical Test Center (CTC) every two years and a phone interview every other year (on uneven years). Sample collection and biobanking will be performed every two years and online questionnaires will be filled out on an annual basis.

The primary goals are to study the variation observed across different individuals in disease susceptibility, clinical phenotypes, and therapeutic responses. The study aims at studying the complex interplay and relative contribution of different omics, physiological characteristics and lifestyle on disease pathogenesis and progression and to evaluate how these effects are mediated.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 30000
• Est. completion date: December 31, 2045
• Est. primary completion date: December 31, 2045
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Ages 18+, males and females.

Exclusion Criteria:

• Pregnancy.

• Mentally disabled or in general legally non-competent.

• Prisoner or soldier. Soldiers: mandatory service only

• Active cancer

• Fertility Treatments (current)

• Hepatitis ( B, C), chronic or acute

• HIV

• Liver cirrhosis

• Dialysis

• Unstable medical conditions

Related Conditions & MeSH terms

• Adult Disease

Locations

Country	Name	City	State
Israel	Weizmann institute of science	Re?ovot

Sponsors (1)

Lead Sponsor	Collaborator
Weizmann Institute of Science

Country where clinical trial is conducted

Israel, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Adult disease	Development of medical conditions based on participant's self-reporting coded to ICD11.	25 years