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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT01528956
Other study ID # ARAR12B1
Secondary ID COG-ARAR12B1CDR0
Status Completed
Phase N/A
First received February 5, 2012
Last updated May 17, 2016
Start date February 2012

Study information

Verified date May 2016
Source Children's Oncology Group
Contact n/a
Is FDA regulated No
Health authority United States: Federal Government
Study type Observational

Clinical Trial Summary

RATIONALE: Studying samples of blood and tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.

PURPOSE: This research trial studies genes in samples from younger patients with adrenocortical tumor.


Description:

OBJECTIVES:

- To perform whole-genome sequencing, deep sequencing, micro RNA analysis, methylation status, copy number variation analysis, and single-nucleotide polymorphisms (SNPs) analysis in pediatric adrenocortical tumors and compare those results to those of the same patient's normal cells.

OUTLINE: Archived tumor and blood samples are analyzed for whole-genome sequencing, deep sequencing, micro RNA , methylation status, copy variation, and single-nucleotide polymorphisms. Results are then compared with patients' normal cells.


Recruitment information / eligibility

Status Completed
Enrollment 10
Est. completion date
Est. primary completion date May 2016
Accepts healthy volunteers No
Gender Both
Age group N/A to 21 Years
Eligibility DISEASE CHARACTERISTICS:

- Banked tumor and blood samples obtained from patients enrolled on COG-ARAR0332 in North America and Brazil

PATIENT CHARACTERISTICS:

- Not specified

PRIOR CONCURRENT THERAPY:

- Not specified

Study Design

Observational Model: Case-Only, Time Perspective: Retrospective


Related Conditions & MeSH terms


Intervention

Genetic:
DNA methylation analysis

RNA analysis

gene expression analysis

nucleic acid sequencing

polymorphism analysis


Locations

Country Name City State
n/a

Sponsors (2)

Lead Sponsor Collaborator
Children's Oncology Group National Cancer Institute (NCI)

Outcome

Type Measure Description Time frame Safety issue
Primary Identification of genetic factors affecting adrenocortical tumors No
Primary Comprehensive catalog of altered genes in adrenocortical samples No
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