Studying Genes in Samples From Younger Patients With Adrenocortical Tumor

Adrenocortical Carcinoma Clinical Trial

Official title:

Using New Approaches for Genomics Studies in Pediatric Adrenocortical Tumors: Whole Genome Sequencing; Deep Sequencing; miRNA; methDNA and SNP 6.0

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01528956
• Other study ID #: ARAR12B1
• Secondary ID: COG-ARAR12B1CDR0
• Status: Completed
• Phase: N/A
• First received: February 5, 2012
• Last updated: May 17, 2016
• Start date: February 2012

Study information

• Verified date: May 2016
• Source: Children's Oncology Group
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Federal Government
• Study type: Observational

Clinical Trial Summary

RATIONALE: Studying samples of blood and tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.

PURPOSE: This research trial studies genes in samples from younger patients with adrenocortical tumor.

Description:

OBJECTIVES:

• To perform whole-genome sequencing, deep sequencing, micro RNA analysis, methylation status, copy number variation analysis, and single-nucleotide polymorphisms (SNPs) analysis in pediatric adrenocortical tumors and compare those results to those of the same patient's normal cells.

OUTLINE: Archived tumor and blood samples are analyzed for whole-genome sequencing, deep sequencing, micro RNA , methylation status, copy variation, and single-nucleotide polymorphisms. Results are then compared with patients' normal cells.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 10
• Est. primary completion date: May 2016
• Accepts healthy volunteers: No
• Gender: Both
• Age group: N/A to 21 Years

Eligibility

DISEASE CHARACTERISTICS:

• Banked tumor and blood samples obtained from patients enrolled on COG-ARAR0332 in North America and Brazil

PATIENT CHARACTERISTICS:

• Not specified

PRIOR CONCURRENT THERAPY:

• Not specified

Study Design

Observational Model: Case-Only, Time Perspective: Retrospective

Related Conditions & MeSH terms

• Adrenal Cortex Neoplasms
• Adrenocortical Carcinoma

Intervention

Genetic:
• DNA methylation analysis

• RNA analysis

• gene expression analysis

• nucleic acid sequencing

• polymorphism analysis

Locations

Country	Name	City	State
n/a

Sponsors (2)

Lead Sponsor	Collaborator
Children's Oncology Group	National Cancer Institute (NCI)

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Identification of genetic factors affecting adrenocortical tumors			No
Primary	Comprehensive catalog of altered genes in adrenocortical samples			No