Adrenal Tumor Clinical Trial
Official title:
Diagnostic Value of 18FDG PET/CT Textural Indices in Patients With an Adrenal Lesion
Tumors are characterized by a great heterogeneity. Characterizing this intra-tumor
heterogeneity is a major challenge in oncology to improve the therapeutic management and move
towards personalized medicine adapted to each patient. However, intra-tumor heterogeneity
remains rarely used for diagnostic purposes The discovery of an adrenal mass can occur in
different circumstances. Detection of an adrenal mass can be done in a context of secreting
syndrome, in the assessment of an extra-adrenal neoplasia or fortuitously when performing an
imaging for another reason. The etiologies are numerous (cortical tumors, medullary tumors,
metastatic lesion of a extra-adrenal neoplasia, others). The adrenal masses can be divided
into two categories, depending on whether they are hyperfunctional or not. In patients
without an oncological history, an adrenal mass discovered is most often a benign adenoma,
but requires an endocrine assessment. In patients with known primary cancer, approximately
30% of the adrenal masses are malignant.
In all cases, the diagnostic procedure includes an imaging assessment to characterize the
lesion and an endocrine assessment. CT scan performed without and after intravenous iodinated
contrast agent injection is the first-line examination to assess an adrenal mass.
18F-FDG-PET may be indicated as second-line for characterizing an adrenal mass. Adrenal tumor
SUVmax (Standard Uptake Value) and adrenal tumor SUVmax / liver SUVmax ratio are routinely
used to determine the malignancy of a lesion. Although very useful for assessing the glucose
metabolism of a given lesion, these parameters do not allow assessing the heterogeneity of
tumor uptake. The texture analysis corresponds to an analysis of the spatial distribution of
FDG uptake, and allows, by the calculation of many indices, an evaluation of the
heterogeneity of the tumors.
The hypothesis of our study is that the texture parameters could have an additional
diagnostic value to improve the performance of conventional quantitative parameters to
determine the malignancy of a lesion.
The objective of this study is to investigate the diagnostic value of texture indices in a
large cohort of patients presenting an adrenal lesion
n/a
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