Adherence in Chronic Adrenal Insufficiency

Status Recruiting

Clinical Trial Summary

Adherence, concerns and satisfaction with information in German patients with adrenal insufficiency as well as the influence of a standardized education program will be assessed by a compared cross-sectional and longitudinal study.

Clinical Trial Description

Patients with adrenal insufficiency (AI) require a lifelong replacement therapy with glucocorticoids (GC). To avoid over- and under- replacement, an individual daily dose scheme and adequate dose adjustment during stressful events is essential. Recent patient surveys revealed nonadherence to treatment, concerns about GC and dissatisfaction with the provided information.

The aim of this trial is to evaluate the adherence, concerns and satisfaction with information in German patients with primary and secondary AI (PAI/SAI) and the influence of a standardized education program.

Patients with AI on GC therapy will be assessed by questionnaire, including the Medication Adherence Report Scale* (MARS), Beliefs about Medicines Questionnaire* (BMQ, adapted for AI) and Satisfaction with Information about Medicines Scale* (SIMS).*©Professor Rob Horne.

The study includes one cross-sectional-analysis and one longitudinal study (patient survey before and after participation at the standardized education program in Germany). ;

Study Design

Related Conditions & MeSH terms

Adrenal Insufficiency

Clinical Trial Details

NCT number	NCT03399383
Study type	Interventional
Source	Wuerzburg University Hospital
Contact	Stefanie Hahner, Prof. Dr.
Phone	0049-931-201-39200
Email	Hahner_S@ukw.de
Status	Recruiting
Phase	N/A
Start date	September 2016
Completion date	December 2018

View Details

See also
Status	Clinical Trial	Phase
Enrolling by invitation	`NCT03282487` - Optimising Steroid Replacement in Patients With Adrenal Insufficiency	Phase 4
Not yet recruiting	`NCT05716607` - Treatment Study in Patients Treated With Both Insulin & Hydrocortisone	N/A
Not yet recruiting	`NCT06435481` - Tolerability and Acceptance of Two Oral Hydrocortisone Compounding Formulation for Pediatrics	Phase 4
Completed	`NCT01428336` - Value of 25 mcg Cortrosyn Stimulation Test	N/A
Completed	`NCT00851942` - Determination of Method-specific Normal Cortisol and Adrenal Hormone Responses to the Short Synacthen Test	Phase 4
Withdrawn	`NCT00368381` - Hydrocortisone Versus Hydrocortisone Plus Fludrocortisone for the Treatment of Adrenal Insufficiency in Severe Sepsis	Phase 4
Active, not recruiting	`NCT04519580` - Improved Diagnostics and Monitoring of Polymyalgia Rheumatica
Recruiting	`NCT06008184` - Real-time Monitoring of Cortisol - Comparison of Cortisol Levels in Four Biological Fluids
Completed	`NCT03013166` - THIN Database Study: Resource Use and Outcomes in Patients With Adrenal Insufficiency Prescribed Hydrocortisone: Immediate, or Modified Release, or Prednisolone
Enrolling by invitation	`NCT02282150` - Modified-release Compared to Conventional Hydrocortisone on Diurnal Fatigue in Secondary Hypoadrenalism	Phase 4
Completed	`NCT02934399` - Dynamic Hormone Diagnostics in Endocrine Disease
Completed	`NCT03000231` - Circadian Function and Cardio-metabolic Risk in Adrenal Insufficiency
Completed	`NCT01960530` - An Investigational Study of Hydrocortisone	Phase 1
Completed	`NCT00552487` - Isolated ACTH Deficiency in Patients With Hashimoto Thyroiditis	N/A
Completed	`NCT00575341` - Dehydroepiandrosterone Substitution in Adolescent and Young Women With Central Adrenal Insufficiency	Phase 3
Completed	`NCT00471900` - Six Months DHEA Treatment in Female Adrenal Failure	N/A
Completed	`NCT03294876` - Rheumatoid Arthritis Adrenal Recovery Study
Completed	`NCT03709381` - Effect of Adrenocorticotropic Hormone on Vascular Endothelial Growth Factor Release in Children Study	Early Phase 1
Recruiting	`NCT05639127` - The Treatment of Adrenal Crisis With Inhaled Prednisolone	Early Phase 1
Completed	`NCT04488432` - Endocrine, Bone And Metabolic Disorders In Adults After Allogeneic Stem-cell Transplant