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Adoptive Cellular Immunotherapy clinical trials

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NCT ID: NCT03983759 Recruiting - Clinical trials for Small Cell Lung Cancer

Study of Sintlimab Maintenance Therapy in Patients With Extensive Small Cell Lung Cancer

Start date: June 20, 2019
Phase: Phase 2
Study type: Interventional

Small cell lung cancer is a highly aggressive malignancy. Currently, there is no effective regimen for patients after the progression offirst-line chemotherapy. The prognosis of patients with extensive disease is very poor, and the improved therapeutic efficacy is urgently needed. Most patients with small cell lung cancer have a long history of smoking, and the tumor mutation burden is relatively high, which provides potential for immunological checkpoint inhibitors represented by PD-1 antibodies. A number of studies have shown that chemotherapy combined with adoptive cellular immunotherapy could prolong the survival of patients. This study is a clinical study to explore the efficacy and safety of maintenance therapy with sintilimab after 4-6 cycles of first-line chemotherapy combined with adoptive cellular immunotherapy in patients with advanced small cell lung cancer.