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Clinical Trial Summary

The purpose of this study is to identify potential markers for curve progression in adolescent idiopathic scoliosis (AIS). Despite its prevalence and impact on child health, the etiology of AIS and molecular mechanisms underlying its development and progression remain poorly understood. Clinical criteria and features cannot adequately predict which children, diagnosed with mild disease, will undergo subsequent curve progression requiring intervention. The investigators hypothesize that alterations in specific genetic markers will be correlated with the progression of AIS curves over time. Thus, these markers could be used in the future to develop a reliable, inexpensive and relatively non-invasive cell based diagnostic test to (1) predict spinal curve progression in AIS, (2) select patients likely to benefit from early surgical intervention, and (3) potentially screen for asymptomatic children at risk of developing idiopathic scoliosis.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT02315729
Study type Observational
Source University of Colorado, Denver
Contact jiandong hao
Phone 303-724-7457
Email jiandong.hao@cuanschutz.edu
Status Recruiting
Phase
Start date November 2016
Completion date December 2028

See also
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