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MR Imaging of Fat Deposition in Adolescents With First Time Antipsychotic Use

Adiposity Clinical Trial

Official title:
MR Imaging of Fat Deposition in Adolescents With First Time Antipsychotic Use

Clinical Trial Summary

This study will focus on a population of antipsychotic (AP) naïve adolescents and young adults and will measure fat accumulation in relation to exposure to atypical antipsychotic medications.

Clinical Trial Description

Atypical Antipsychotics (AAPs) are known to cause metabolic dysfunction, and adolescents are especially vulnerable to this effect. The anthropometric measures routinely used to monitor these metabolic side effects may, in fact, underestimate risk in the pediatric population as they are not a good index of hepatic and visceral adipose tissue.

This study will measure fat accumulation over a 12 week period in adolescents and young adults taking an AAP for the first time. MRI imaging will measure hepatic, and visceral adipose tissue at baseline and study end. An Oral Glucose Tolerance Test will measure glucose resistance and insulin sensitivity. In an exploratory fashion, investigators will also image the brain to assess for volumetric changes which may occur in association with AAP treatment and changes in metabolic indices. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02744313
Study type Observational
Source Centre for Addiction and Mental Health
Contact
Status Completed
Phase
Start date April 2016
Completion date April 2018
View Details
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